Main Article Content
Abstract
Cissus quadrangularis L. is a perennial herb belongs to Vitaceae. Traditionally used in the treatment of bone related issues such as Fracture, Pain, Inflammation, Osteoporosis, Rheumatoid and Osteoarthritis. The Preliminary Phytochemical screening indicates the presence of alkaloids, flavonoids, tannins, saponins and phenolic compounds. The aim of this study is to investigate the Phytochemical and Pharmacological evaluation of ethanol extract of Cissus quadrangularis L. In vitroDiuretic and Anti- inflammatory activity performed by using calcium oxalate method and Membrane stabilization assay. The extract of various concentrations were tested using cystone as positive control and 500,250,100,50 and 10 µg/L concentrations were prepared and performed. Results showed that the ethanol extract at concentration 500mg/ml effective against the inflammation and proved to treat the kidney stones as a diuretic.
Keywords
Cissus quadrangularis Linn
Phytochemicals
Diuretic
Antiinflammatory
Article Details
How to Cite
Phytochemical and Pharmacological Evaluation of Cissus quadrangularis Linn. (2025). International Journal of Research in Pharmacology & Pharmacotherapeutics, 14(2), 396-407. https://doi.org/10.61096/ijrpp.v14.iss2.2025.396-407
How to Cite
Phytochemical and Pharmacological Evaluation of Cissus quadrangularis Linn. (2025). International Journal of Research in Pharmacology & Pharmacotherapeutics, 14(2), 396-407. https://doi.org/10.61096/ijrpp.v14.iss2.2025.396-407
References
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1. C. P. Khare, Indian Medicinal Plants An illustrated Dictionary-springer
2. Singhal HK and Neetu A, “Review on the Diuretic activity of Ayurvedic herbs”, Global Journal Research Medicinal Plants and Indigenous Medicine 2013; 2(11): 758-93.
3. Ciddi Veeresham, Natural products derived from plants as a source of drugs, Journal of Advanced Pharmaceutical Technology Research 2012; 3(4): 200– 201.
4. Chitale P.K, A comparative study of Ayurveda and treatment of Indian drugs, Sri Satguru Publication, Delhi, 1997; pp. 154
5. Mohd Mazida, Taqi Ahmed Khanb and Firoz Mohammada, Medicinal Plants of Rural India: A Review of Use by Indian Folks, Indo Global Journal of Pharmaceutical Sciences, 2012; 2(3): 286-304.
6. Singh R, Medicinal Plants: A Review, Journal of Plant Sciences. Special Issue: Medicinal Plants. Vol. 3, No. 1-1, 2015, pp. 50-55.
7. Refaz Ahmad Dar, Mohd Shahnawaz and Parvaiz Hassan Qazi. General overview of medicinal plants: A review, The Journal of Phytopharmacology 2017; 6(6): 349-351.
8. Shah U. Cissus quadrangularis L.: Phytochemicals, Traditional uses and Pharmacological Activities - A review, International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3 (4): 41-44
9. Austin A., Jagdeesan M., Gastric and duodenal antiulcer and cytoprotective effects of Cissus quadrangularis Linn. variant II in rats, Nig J Nat Prod Med, 2002, 6, 1-7
10. Singh SP., Mishra N., Dixit KS., Singh N., Kohli RP., “An experimental study of Analgesic Activity of Cissus quadrangularis”, Indian Journal of Pharmacology, 16(3), 1984, 162-63.
11. Jainu M., Devi CSS., Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer a comparative study with sucralfate, J. Med. Food, 2004:7, 372–376
12. Anoop A., Jagdeesan M., Gastric and duodenal antiulcer and cytoprotective effect of Cissus quadrangularis Linn. variant II in rats, Nigerian Journal of Natural Products and Medicine, 2002, 6, 1–7.
13. Mazni Abu Zarin, Joo Shun Tan, Paramasivam Murugan and Rosma Ahmad. Investigation of potential anti-urolithiatic activity from different types of Musa pseudo-stem extracts in inhibition of calcium oxalate crystallization. BMC Complementary Medicine and Therapies (2020) 20:317.
14. SarmisthaSaha, Ramtej J. Verma Inhibition of calcium oxalate crystallization invitro by an extract of Bergenia ciliate. Arab Journal of Urology. (2013) 11, 187-192.
15. Gopinathan N, Harish.G, Aswinkumar.G., Chitra.K., Umamaheswara reddy.C, Investigation of invitro Antiarthritic, Anti-inflammatory and Anti- Oxidant activity of Tectona grandis Linn, Indian drugs, 47 (6), 2010, 74- 76.
References
1. C. P. Khare, Indian Medicinal Plants An illustrated Dictionary-springer
2. Singhal HK and Neetu A, “Review on the Diuretic activity of Ayurvedic herbs”, Global Journal Research Medicinal Plants and Indigenous Medicine 2013; 2(11): 758-93.
3. Ciddi Veeresham, Natural products derived from plants as a source of drugs, Journal of Advanced Pharmaceutical Technology Research 2012; 3(4): 200– 201.
4. Chitale P.K, A comparative study of Ayurveda and treatment of Indian drugs, Sri Satguru Publication, Delhi, 1997; pp. 154
5. Mohd Mazida, Taqi Ahmed Khanb and Firoz Mohammada, Medicinal Plants of Rural India: A Review of Use by Indian Folks, Indo Global Journal of Pharmaceutical Sciences, 2012; 2(3): 286-304.
6. Singh R, Medicinal Plants: A Review, Journal of Plant Sciences. Special Issue: Medicinal Plants. Vol. 3, No. 1-1, 2015, pp. 50-55.
7. Refaz Ahmad Dar, Mohd Shahnawaz and Parvaiz Hassan Qazi. General overview of medicinal plants: A review, The Journal of Phytopharmacology 2017; 6(6): 349-351.
8. Shah U. Cissus quadrangularis L.: Phytochemicals, Traditional uses and Pharmacological Activities - A review, International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3 (4): 41-44
9. Austin A., Jagdeesan M., Gastric and duodenal antiulcer and cytoprotective effects of Cissus quadrangularis Linn. variant II in rats, Nig J Nat Prod Med, 2002, 6, 1-7
10. Singh SP., Mishra N., Dixit KS., Singh N., Kohli RP., “An experimental study of Analgesic Activity of Cissus quadrangularis”, Indian Journal of Pharmacology, 16(3), 1984, 162-63.
11. Jainu M., Devi CSS., Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer a comparative study with sucralfate, J. Med. Food, 2004:7, 372–376
12. Anoop A., Jagdeesan M., Gastric and duodenal antiulcer and cytoprotective effect of Cissus quadrangularis Linn. variant II in rats, Nigerian Journal of Natural Products and Medicine, 2002, 6, 1–7.
13. Mazni Abu Zarin, Joo Shun Tan, Paramasivam Murugan and Rosma Ahmad. Investigation of potential anti-urolithiatic activity from different types of Musa pseudo-stem extracts in inhibition of calcium oxalate crystallization. BMC Complementary Medicine and Therapies (2020) 20:317.
14. SarmisthaSaha, Ramtej J. Verma Inhibition of calcium oxalate crystallization invitro by an extract of Bergenia ciliate. Arab Journal of Urology. (2013) 11, 187-192.
15. Gopinathan N, Harish.G, Aswinkumar.G., Chitra.K., Umamaheswara reddy.C, Investigation of invitro Antiarthritic, Anti-inflammatory and Anti- Oxidant activity of Tectona grandis Linn, Indian drugs, 47 (6), 2010, 74- 76.
2. Singhal HK and Neetu A, “Review on the Diuretic activity of Ayurvedic herbs”, Global Journal Research Medicinal Plants and Indigenous Medicine 2013; 2(11): 758-93.
3. Ciddi Veeresham, Natural products derived from plants as a source of drugs, Journal of Advanced Pharmaceutical Technology Research 2012; 3(4): 200– 201.
4. Chitale P.K, A comparative study of Ayurveda and treatment of Indian drugs, Sri Satguru Publication, Delhi, 1997; pp. 154
5. Mohd Mazida, Taqi Ahmed Khanb and Firoz Mohammada, Medicinal Plants of Rural India: A Review of Use by Indian Folks, Indo Global Journal of Pharmaceutical Sciences, 2012; 2(3): 286-304.
6. Singh R, Medicinal Plants: A Review, Journal of Plant Sciences. Special Issue: Medicinal Plants. Vol. 3, No. 1-1, 2015, pp. 50-55.
7. Refaz Ahmad Dar, Mohd Shahnawaz and Parvaiz Hassan Qazi. General overview of medicinal plants: A review, The Journal of Phytopharmacology 2017; 6(6): 349-351.
8. Shah U. Cissus quadrangularis L.: Phytochemicals, Traditional uses and Pharmacological Activities - A review, International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3 (4): 41-44
9. Austin A., Jagdeesan M., Gastric and duodenal antiulcer and cytoprotective effects of Cissus quadrangularis Linn. variant II in rats, Nig J Nat Prod Med, 2002, 6, 1-7
10. Singh SP., Mishra N., Dixit KS., Singh N., Kohli RP., “An experimental study of Analgesic Activity of Cissus quadrangularis”, Indian Journal of Pharmacology, 16(3), 1984, 162-63.
11. Jainu M., Devi CSS., Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer a comparative study with sucralfate, J. Med. Food, 2004:7, 372–376
12. Anoop A., Jagdeesan M., Gastric and duodenal antiulcer and cytoprotective effect of Cissus quadrangularis Linn. variant II in rats, Nigerian Journal of Natural Products and Medicine, 2002, 6, 1–7.
13. Mazni Abu Zarin, Joo Shun Tan, Paramasivam Murugan and Rosma Ahmad. Investigation of potential anti-urolithiatic activity from different types of Musa pseudo-stem extracts in inhibition of calcium oxalate crystallization. BMC Complementary Medicine and Therapies (2020) 20:317.
14. SarmisthaSaha, Ramtej J. Verma Inhibition of calcium oxalate crystallization invitro by an extract of Bergenia ciliate. Arab Journal of Urology. (2013) 11, 187-192.
15. Gopinathan N, Harish.G, Aswinkumar.G., Chitra.K., Umamaheswara reddy.C, Investigation of invitro Antiarthritic, Anti-inflammatory and Anti- Oxidant activity of Tectona grandis Linn, Indian drugs, 47 (6), 2010, 74- 76.