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Dec 5, 2024
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Dec 5, 2024
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Abstract

This study evaluates the antipyretic and antioxidant activities of the ethyl acetate extract of Barleria prionitis Linn. root. Utilizing both in vitro and in vivo methods, the extract demonstrated significant efficacy in free radical scavenging and reducing yeast-induced pyrexia in Albino wistar rats. Phytochemical screening revealed the presence of phenolics, tannins, alkaloids, and other bioactive compounds. The antioxidant activity was quantified using the DPPH assay, with an IC50 value comparable to ascorbic acid. In vivo studies showed a dose-dependent reduction in rectal temperature. These findings validate the traditional medicinal uses of B. prionitis Linn. and suggest its potential as a natural therapeutic agent for fever and oxidative stress-related conditions.

Keywords

Barleria prionitis Linn Antipyretic activity Antioxidant activity Phytochemicals DPPH assay Ethyl acetate extract Natural medicine Pyrexia Free radical scavenging

Article Details

How to Cite
J. Naveen, Indumathy, N. Lakshmi, & S. Santhosh. (2024). Evaluation of antipyretic and antioxidant activity of Barleria prionitis Linn. Root extract against brewer’s yeast induced pyrexia in albino wistar rat. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(4), 643-654. Retrieved from https://ijrpp.com/ijrpp/article/view/599
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