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Abstract
The study was conducted to screen the antipyretic activity of alcoholic extract of the Fruits of Terminalia Pallida. Terminalia Pallida is a potent medicinal plant in the Indian systems of medicine. Traditionally it is used as a cardioprotective, antihyperlipidemic, antiatherogenic, anti-ulcer, etc. In the present study the alcoholic extract of the seed of Terminalia Pallida was studied for their antipyretic activity by milk induced pyrexia in rabbits. It was observed that the alcoholic extract produced significant antipyretic activity (p < 0.05). The extract showed marked antipyretic activity in a dose dependent manner.
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References
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- [2]. Chattopadhyay, D., G. Arunachalam, L.Ghosh, K. Rajendran, A.B. Mandal and S.K.Bhattacharya, 2005. Antipyretic activity of Alstonia macrophylla Wall ex A. DC: An ethnomedicine of Andaman Islands. Journal of Pharmacy and Pharmaceutical Science, 8: 558-564.
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- Medicine, 330: 1880-1886.
- [4]. Veugelers, P.J., J.M. Kaldor, S.A. Strathdee, K.A. Page-Shafer, M.T. Schechter, R.A. Coutinho, I.P. Keet and G.J. van Griensven, 1997. Incidence and prognostic significance of symptomatic primary human immunodeficiency virus type 1 infection in homosexual men. Journal of Infectious Disease, 176: 112-117.
- [5]. Nammi S, Boini MK, Lodagala SD et al. The juice of fresh leaves of Catharanthus roseus Linn. reduce blood glucose in normal and alloxan diabetic rabbits. BMC Complementary and Alternative Medicine, 3, 2003, 4-7.
- [6]. Brithsh Veterinary Association Animal Welfare Foundation (BVAAWF), Fund for replacement of Animals in Medical Experiments (FRAME), Royal Society for the Prevention of Cruelty to Animal (RSPCA), Universities Federation for Animal Welfare (UFAW) Joint working group on Refinement. Refinement in rabbit husbandry. Lab Anim 27, 1993, 301-329.
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- [8]. Kokate C.K. Purohit A.P., Gokhale S.B., Text book of Pharmacognosy, Nirali Prakashan, Pune VIth edition, 1997, 123-124.
- [9]. Chandel R.S. & Rastogi R.P., Phytochemistry,19, 1980, 1889-1902.
- [10]. Dona, Alexander Johnson, Plant micro techniques, Ist edition, 192.
- [11]. Mutalik S, Paridhavi K, Rao CM et al. Antipyretic and analgesic effect of leaves of Solanum Melongena Linn. in rodents. Indian J Pharmacol, 35, 2003,312-315.
- [12]. Grover JK. Experiments in Pharmacy and Pharmacology. 1st ed.,2, 1990,155.
- [13]. Brasseur, T., 1989. Antiinflammatory properties of flavonoids. Journal de pharmacie de Belgique,
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- [14]. Vimala, R., S. Nagarajan, M. Alam, T. Susan and S. Joy, 1997. Anti-inflammatory and antipyretic
- activity of Michelia champaca Linn.(White variety), Ixora brachiata Roxb. And Rhynchosia cana
- (wild.) D. C. flower extract. Indian Journal of experimental Biology, 35: 1310-1314
References
[1]. Ramarao AV, Gunjar MK. Drugs from plant resources an overview, Pharma times.1990; 22:19-27.
[2]. Chattopadhyay, D., G. Arunachalam, L.Ghosh, K. Rajendran, A.B. Mandal and S.K.Bhattacharya, 2005. Antipyretic activity of Alstonia macrophylla Wall ex A. DC: An ethnomedicine of Andaman Islands. Journal of Pharmacy and Pharmaceutical Science, 8: 558-564.
[3]. Spacer, C.B. and C.D. Breder, 1994. The neurologic basis of fever. New England Journal of
Medicine, 330: 1880-1886.
[4]. Veugelers, P.J., J.M. Kaldor, S.A. Strathdee, K.A. Page-Shafer, M.T. Schechter, R.A. Coutinho, I.P. Keet and G.J. van Griensven, 1997. Incidence and prognostic significance of symptomatic primary human immunodeficiency virus type 1 infection in homosexual men. Journal of Infectious Disease, 176: 112-117.
[5]. Nammi S, Boini MK, Lodagala SD et al. The juice of fresh leaves of Catharanthus roseus Linn. reduce blood glucose in normal and alloxan diabetic rabbits. BMC Complementary and Alternative Medicine, 3, 2003, 4-7.
[6]. Brithsh Veterinary Association Animal Welfare Foundation (BVAAWF), Fund for replacement of Animals in Medical Experiments (FRAME), Royal Society for the Prevention of Cruelty to Animal (RSPCA), Universities Federation for Animal Welfare (UFAW) Joint working group on Refinement. Refinement in rabbit husbandry. Lab Anim 27, 1993, 301-329.
[7]. Dr. Senthil P.D. HPTLC Qualitative Analysis of Pharmaceutical formations, 1972,1-71
[8]. Kokate C.K. Purohit A.P., Gokhale S.B., Text book of Pharmacognosy, Nirali Prakashan, Pune VIth edition, 1997, 123-124.
[9]. Chandel R.S. & Rastogi R.P., Phytochemistry,19, 1980, 1889-1902.
[10]. Dona, Alexander Johnson, Plant micro techniques, Ist edition, 192.
[11]. Mutalik S, Paridhavi K, Rao CM et al. Antipyretic and analgesic effect of leaves of Solanum Melongena Linn. in rodents. Indian J Pharmacol, 35, 2003,312-315.
[12]. Grover JK. Experiments in Pharmacy and Pharmacology. 1st ed.,2, 1990,155.
[13]. Brasseur, T., 1989. Antiinflammatory properties of flavonoids. Journal de pharmacie de Belgique,
44: 235-241.
[14]. Vimala, R., S. Nagarajan, M. Alam, T. Susan and S. Joy, 1997. Anti-inflammatory and antipyretic
activity of Michelia champaca Linn.(White variety), Ixora brachiata Roxb. And Rhynchosia cana
(wild.) D. C. flower extract. Indian Journal of experimental Biology, 35: 1310-1314