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May 15, 2024
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May 15, 2024
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Abstract

The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and also due to hyper secretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of Hemidesmus Indicus. Study was carried out, by using three methods i.e., alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQHI and ALHI, 10mg/kg Omeoprazole and 50 mg/kg Ranitidine.


To evaluate the antiulcer activity of aqueous and alcoholic extracts of Hemidesmus Indicus leaves (AQHI and ALHI) at 250 doses using different experimentally induced gastric ulcer models in rats.


Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis.


 In alcohol-induced ulcers, AQHI and ALHI were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with Hemidesmus Indicus were dose dependent.  The results suggest that AQHI and ALHI possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQHI and ALHI can be attributed to its cytoprotective and antisecretory action.

Keywords

Hemidesmus Indicus, antisecretory, cytoprotective, gastric ulcer, alcohol induced ulcers, paracetamol-induced ulcers and stress induced ulcers.

Article Details

How to Cite
Anusha Rasamalla, Sripriya Abboju, Tallapally Varshitha, Kyathapaka Vasu, Puli Satish, Somidi Pushpa Latha, & A. Venkatesham. (2024). Phytochemical Screening And Evaluation of Antiulcer Activity of Hemidesmus Indicus Leaves. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(2), 101-110. Retrieved from https://ijrpp.com/ijrpp/article/view/539
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