Article Sidebar

Submitted
May 15, 2024
Published
May 15, 2024
Download
PDF
Statistic
Read Counter : 21 Download : 32

Main Article Content

Abstract

The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and also due to hyper secretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of Hemidesmus Indicus. Study was carried out, by using three methods i.e., alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQHI and ALHI, 10mg/kg Omeoprazole and 50 mg/kg Ranitidine.


To evaluate the antiulcer activity of aqueous and alcoholic extracts of Hemidesmus Indicus leaves (AQHI and ALHI) at 250 doses using different experimentally induced gastric ulcer models in rats.


Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis.


 In alcohol-induced ulcers, AQHI and ALHI were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with Hemidesmus Indicus were dose dependent.  The results suggest that AQHI and ALHI possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQHI and ALHI can be attributed to its cytoprotective and antisecretory action.

Keywords

Hemidesmus Indicus, antisecretory, cytoprotective, gastric ulcer, alcohol induced ulcers, paracetamol-induced ulcers and stress induced ulcers.

Article Details

How to Cite
Anusha Rasamalla, Sripriya Abboju, Tallapally Varshitha, Kyathapaka Vasu, Puli Satish, Somidi Pushpa Latha, & A. Venkatesham. (2024). Phytochemical Screening And Evaluation of Antiulcer Activity of Hemidesmus Indicus Leaves. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(2), 101-110. Retrieved from https://ijrpp.com/ijrpp/article/view/539
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. 1. Burks TF. Principles of Pharmacology. United States of America: International Thomson publishing Inc; 1995. p. 1063.
  2. 2. Kumar V, Abbas KA, Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th ed. New Delhi: Elsevier Inc; 2004. p. 817.
  3. 3. Peptic ulcer diagram. Available from:www.wanderiner.blogspot.com.
  4. 4. Statistics. Available from:http://www.cureresearch.com/p/peptic_ulcer/statscountry.htm
  5. 5. Danger of ulcer. Available from:http://www.murrasaca.com/Gastriculcer.htm.
  6. 6. Allison MC, Howatson AG, Caroline MG.Gastrointestinal damage associated with the use of nonsteriodal anti-inflammatory drugs. N Engl J Med 1992; 327: 749–54.
  7. 7. Lenz HJ, Ferrari-Taylor J, Isenberg JI. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology 1983; 85: 1082-7.
  8. 8. Cohen S, Booth GH Jr. Gastric acid secretion and lower-esophageal - sphincter pressure in response to coffee and caffeine. N Engl J Med 1975; 293: 897–9.
  9. 9. Feldman EJ, Isenberg JI, Grossman MI. Gastric acid and gastrin response to decaffeinated coffee and a peptone meal. JAMA 1981; 246: 248–50.
  10. 10. Dubey P, Sundram KR, Nundy S. Effect of tea on gastric acid secretion. Dig Dis Sci 1984; 29: 202–6.
  11. 11. Korman MG, Hansky J, Eaves ER, Schmidt GT. Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology 1983;85: 871– 4.
  12. 12. Katchinski BD, Logan RFA, Edmond M, Langman MJS. Duodenal ulcer and refined carbohydrate intake, a case-control study assessing dietary fiber and refined sugar intake. Gut 1990; 31: 993–6.
  13. 13. Suadicani P, Hein HO, Gyntelberg F. Genetic and life-style determinants of peptic ulcer, a study of 3387 men aged 54 to 74 years, the copenhagen male study. Scand J Gastroenterology 1999; 34: 12 – 7.
  14. 14. Yudkin J. Eating and ulcers. BMJ 1980; Feb. 16: 483 [letter]
  15. 15. Sonnenberg A. Dietary salt and gastric ulcer. Gut 1986; 27: 1138 – 42.
  16. 16. Pfeiffer CJ, Cho CH, Cheema A, Saltman D. Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc. Eur J Pharmacology, 1980; 61: 347– 53.
  17. 17. Shive W, Snider RN, DuBilier B. Glutamine in treatment of peptic ulcer. TexasState J Med. 1957; 11: 840.
  18. 18. Chaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, Goel KR. Effect of ethanolic extract of Eugenia Jambolana seeds on gastric ulceration and secretion in rats. Indian J PhysiolPharmacol 2007; 51(2): 131-140.
  19. 19. Nadkarni KM. Indian Materia Medica. 2 nd ed. Bombay: Popular Prakashan; 1976.vol 2 p. 394-95.
  20. 20. Hisham A, Pieters L A C, Claeys M, Esmansa E, Dommisse R and VlietinckA J (1991). Squamocin-28-one and panalicin, two acetogenins from Uvarianarum. Phytochemistry 30(2): 545-548.