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Abstract
The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and also due to hypersecretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of Canthium Dicoccum. Study was carried out, by using three methods i.e.,alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQCR and ALCR, 10mg/kg Omeoprazole and 50 mg/kg Ranitidine. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis. In alcohol-induced ulcers, It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with Canthium Dicoccum were dose dependent. The results suggest that AQCR and ALCR possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQCR and ALCR can be attributed to its cytoprotective and antisecretory action.
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References
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- 6. Kassuya CA, Cremoneze A, Barros LFL, Simas AS, Lapa FR, Mello-Silva R, Stefanello ME, Zampronio AR (2009). Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). Journal of Ethnopharmacology 124: 369-376.
- 7. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR (2000). Macrophages in rheumatoid arthritis. Arthritis Research 2: 189-202.
- 8. White M (1999). Mediators of inflammation and inflammatory process. The Journal of Allergy and Clinical Immunology 103: S378-S381.
- 9. Obreja O, Rathee PK, Lips KS, Distler C, Kress M (2002). IL-1 beta potentiates heatactivated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C. The Journal of the Federation of American Societies for Experimental Biology 16: 1497-1503.
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- 14. Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G (2004). Carrageenan induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxigenase-2 expression. British Journal of Pharmacology 142: 331-338.
- 15. Lundberg IE (2000). The role of cytokines, chemokines, and adhesion molecules in the pathogenesis of idiopathic inflammatory myopathies. Current Rheumatology Report 2: 216-224.
- 16. Walsh LJ (2003). Mast cells and oral inflammation. Critical Reviews in Oral Biology and Medicine 14: 188-198.
- 17. Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM (2009). Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells. Journal of Ethnopharmacology 123: 97-105.
- 18. Takeda K, Akira S (2001). Roles of Toll-like receptors in innate immune responses. Genes to Cells 6: 733-742.
- 19. Michaelsson E, Holmdahl M, Engstrom A, Burkhardt H, Scheynius A, Holmdahl R (1995). Macrophages, but not dendritic cells, present collagen to T cells. European Journal of Immunology 25: 2234-2241.
- 20. Chatterjee GK, Pal SP (1984). Search for anti-inflammatory agents from Indian medicinal plants-A review. Indian Drugs 21: 413-419.
- 21. Khan A, Baki M,A Al-Bari MAA, Hasan S, Mosaddik MA, Rahman, MM, Haque ME (2007). Antipyretic activity of roots of Laportea crenulata Gaud in rabbit. Research Journal of Medicine and Medical Sciences 2: 58-61.
References
1. Nathan C (2002). Points of control in inflammation. Nature 420: 846-852.
2. Vodovotz Y, Csete M, Bartels J, Chang S, An G (2008). Translational systems biology of inflammation. PLoS Computational Biology 4: 1-6.
3. Frank MM, Fries LF (1991). The role of complement in inflammation and phagocytosis. Immunology Today 12: 322-326.
4. Franklin PX, Pillai AD, Rathod PD, Yerande S, Nivsarkar M, Padh H, Vasu KK, SudarsanamV (2008). 2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. European Journal of Medicinal Chemistry 43: 129-134.
5. Lucas SM, Rothwell NJ, Gibson RM (2006). The role of inflammation in CNS injuryand disease. British Journal of Pharmacology 147: S232-S240.
6. Kassuya CA, Cremoneze A, Barros LFL, Simas AS, Lapa FR, Mello-Silva R, Stefanello ME, Zampronio AR (2009). Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). Journal of Ethnopharmacology 124: 369-376.
7. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR (2000). Macrophages in rheumatoid arthritis. Arthritis Research 2: 189-202.
8. White M (1999). Mediators of inflammation and inflammatory process. The Journal of Allergy and Clinical Immunology 103: S378-S381.
9. Obreja O, Rathee PK, Lips KS, Distler C, Kress M (2002). IL-1 beta potentiates heatactivated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C. The Journal of the Federation of American Societies for Experimental Biology 16: 1497-1503.
10. Huwiler A, Pfeilschifter J (2009). Lipids as targets for novel anti-inflammatory therapies. Pharmacology and Therapeutics 124: 96-112.
11. Spector WG, Willoughby DA (1963). The inflammatory response. Bacteriological Reviews 27: 117-154.
12. Hurley JV (1972). Acute inflammation. Edinburgh, London, Churchill Livingstone.
13. Samuelsson B, Goldyne M, Granstrom E, Hamberg M, Hammarstrom S, Malmsten C (1978). Prostaglandins and tromboxanes. Annual Reviews of Biochemistry 47: 997- 1029.
14. Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G (2004). Carrageenan induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxigenase-2 expression. British Journal of Pharmacology 142: 331-338.
15. Lundberg IE (2000). The role of cytokines, chemokines, and adhesion molecules in the pathogenesis of idiopathic inflammatory myopathies. Current Rheumatology Report 2: 216-224.
16. Walsh LJ (2003). Mast cells and oral inflammation. Critical Reviews in Oral Biology and Medicine 14: 188-198.
17. Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL, Li CM (2009). Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells. Journal of Ethnopharmacology 123: 97-105.
18. Takeda K, Akira S (2001). Roles of Toll-like receptors in innate immune responses. Genes to Cells 6: 733-742.
19. Michaelsson E, Holmdahl M, Engstrom A, Burkhardt H, Scheynius A, Holmdahl R (1995). Macrophages, but not dendritic cells, present collagen to T cells. European Journal of Immunology 25: 2234-2241.
20. Chatterjee GK, Pal SP (1984). Search for anti-inflammatory agents from Indian medicinal plants-A review. Indian Drugs 21: 413-419.
21. Khan A, Baki M,A Al-Bari MAA, Hasan S, Mosaddik MA, Rahman, MM, Haque ME (2007). Antipyretic activity of roots of Laportea crenulata Gaud in rabbit. Research Journal of Medicine and Medical Sciences 2: 58-61.