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May 3, 2021
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May 3, 2021
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Abstract

Background


Abelmoschusesculentusis traditionally well known for its versatileuses. The present study was carried out to evaluate the antidiabetic action of ethanolic extract of AbelmoschusesculentusinStreptozotocin induced diabetic albino rats.


Methods


To look for the antidiabetic effect, the albino rats were divided into 5groups, each consisting of 6 animals. Diabetes was induced by a single i.p. injection of Streptozotocin at a dose of 50 mg/kg body weight. Standard drug, Glibenclamide and ethanolic extract of Abelmoschusesculentusat doses 200 mg/kg and 400 mg/kg body weight was fed to the rats and it was continued till the end of the study. The blood glucose levels were estimated on day 0, 3, 7, 14 and 21 day. The standard drug and the extract were fed from day 4 onwards.


Results


The antidiabetic property of the extract has shown increasing trendwith increase in dose and there was a gradual decrease in blood glucose levels with increased period of exposure to the test drug.


Conclusions


Results obtained in this study substantiate the anti-diabeticactivity of Abelmoschusesculentus seeds.

Keywords

Antidiabetic Abelmoschusesculentus Streptozotocin

Article Details

How to Cite
Dr.K.AnanthaBabu, Dr.E.N.P.Sainath, & D.Sathish Kumar. (2021). Evaluation of antidiabetic activity of abelmoschusesculentus in streptozotocin induced diabetic rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 6(4), 396-404. https://doi.org/10.61096/ijrpp.v6.iss4.2017.396-404
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