Main Article Content

Abstract

Adrenaline is a recommended drug in advanced life support protocol algorithm. This study is to find out the effect
and outcome of adrenaline administration during cardiac resuscitation in a tertiary care centre. This study was
carried out over a period of two months. Fifty one patients in the intensive care unit were included in this study.
During cardiac resuscitation after defibrillation inj.adrenaline 1mg was given intravenously in 3 to 5 minutes of
interval with maximum of two doses. Only two patients were revived successfully with cardiac resuscitation .This
prospective observational study concludes diabetes and hypertension are the high risk factors for coronary artery
disease. Males are predominantly affected and sedentary life style in females are under high risk. Earlier
administration of adrenaline in shockable rhythm resulted in a worst outcome. Large study group population in
future would clarify the reasons for poor outcome.

Keywords

Adrenaline Cardiac Resuscitation

Article Details

How to Cite
Sudha. R, & Vignesh Prabakaran. (1). Prospective study on the effect and outcome of injection adrenaline administration during cardiopulmonary resuscitation. International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(1), 121-126. https://doi.org/10.61096/ijrpp.v8.iss1.2019.121-126

References

  1. [1]. Kouwenhoven WB, Jude JR, Knickerbocker GG Closed-chest cardiac massage. JAMA 173, 1960, 1064-1067.
  2. [2]. Paradis NA, Martin GB, Rivers EP, et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation.JAMA 263, 1990, 1106–1113
  3. [3]. Field JM, Hazinski MF, Sayre MR, et al. Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 122, 2010, S640–S656.
  4. [4]. Sandroni C.Nolan J,cavallaro.T,Antonelli M. In hospital cardiac arrest: incidence, prognosis and possible measures to improve survival.Intensive care med. 33(2), 2007, 237-245 (pub med)
  5. [5]. Srinath Reddy K, Shah B, Varghese C, Ramadoss A. Responding to the threat of chronic diseases in India.Lancet. 366:1744–1749. doi: 10.1016/S0140-6736(05), 2005, 67343-6.
  6. [6]. Joshi P, Islam S, Pais P, Reddy S, Dorairaj P, Kazmi K, Pandey MR, Haque S, Mendis S, Rangarajan S, Yusuf S. Risk factors for early myocardial infarction in South Asians compared with individuals in other ountries.JAMA. 297, 2007, 286–294. doi: 10.1001/jama.297.3.286.
  7. [7]. Gupta R,Joshi P,Mohan V, Reddy KS,Yusuf S.Epidemiology and causation of coronary heart disease and stroke in India. Heart 94, 2008, 16-26.
  8. [8]. McKeigue PM, Miller GJ, Marmot MG. Coronary heart disease in South Asians: a review.clinEpidemiol 42 , 1989, 579 - 679
  9. [9]. Yusuf S, Hawken S,Ounpuu S,et al.Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case control study.Lancet. sep 11, 364(9438), 2004, 937-952.
  10. [10]. Gupta Retal. serial epidemiological surveys in an urban indian population demonstrate increasing coronary risk factors among the low socioecnonomic strata.J Assoc. physicians India. 51, 2003, 470 -477.
  11. [11]. Hardig BM, Gotberg M, Rundgren M, et al. Physiologic effect of repeated adrenaline (epinephrine) doses during cardiopulmonary resuscitation in the cath lab setting: A randomised porcine study. Resuscitation. 101, 2016, 77–83
  12. [12]. Nordseth T, Olasveengen TM, Kvaloy JT, Wik L, Steen PA, Skogvoll E.Dynamic effects of adrenaline (epinephrine) in out-of-hospital cardiac arrest with initial pulseless electrical activity (PEA). Resuscitation. 83, 2012, 946–52
  13. [13]. Rohan Khera, Paul S. Chan, Michael W. Donnino, Saket Girotra. Hospital Variation in Time to Epinephrine for Non-Shockable In-Hospital Cardiac Arrest. Circulation, CIRCULATIONAHA.116.025459, 2016.
  14. [14]. Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 307, 2012, 1161–8.
  15. [15]. Nakahara S, Tomio J, Takahashi H, et al. Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study. BMJ. 347, 2013, f6829.
  16. [16]. Wang CH, Huang CH, Chang WT, et al. The influences of adrenaline dosing frequency and dosage on outcomes of adult in-hospital cardiac arrest: A retrospective cohort study. Resuscitation. 103, 2016, 125–30.
  17. [17]. Koscik C, Pinawin A, McGovern H, et al. Rapid epinephrine administration improves early outcomes in out-of-hospital cardiac arrest. Resuscitation. 84, 2013, 915–20.
  18. [18]. Dumot JA, Burval DJ, ET AL.Outcome of adult cardiopulmonary resuscitations at a tertiary referral center including results of “limited” resuscitations.Arch intern Med. 161, 2001, 1751-1758.