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Apr 1, 2021
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Apr 1, 2021
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Abstract

Malignant gonadal germ cell tumors are the rare malignant tumors which occurs in young individuals at the peak of their reproductive life between 18- 45yrs. Germ cell tumors are sensitive to chemotherapy as well as radiotherapy . Three and four drugs regimen  increases the survival of 80-90% with increased drug induced toxicity. This study is to find out the efficacy of two drug regimen with cisplatin and etoposide response in malignant gonadal germ cell tumor . The study was carried out in a tertiary care hospital for a period of 21 months. Twenty six patients were selected and six patients were excluded. Prior to treatment all patients were evaluated with basic investigations. αFP and β HCG levels were estimated before and after chemotherapy. Cisplatin 20mg /m² and Etoposide 75mg/m² was given daily for five consecutive days at an interval of 21 days in four cycles. Patients were observed for adverse effects during the course of therapy. Response was evaluated by  evidence of regression of the documented tumors and  measuring serum tumor markers  level . In this study 85% of patients were complete responders and side effects also less during treatment and the follow up period. 5% were partial responders and 10% were non responders. Partial and non responders were recommended for an alternative therapy.

Keywords

α FP β HCG

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Sudha. R, Navajothi. R, & P. K. Muthu kumara samy. (2021). A prospective study on the efficacy of two drug combination chemotherapy in patients with malignant gonadal germ cell tumors . International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(1), 114-120. https://doi.org/10.61096/ijrpp.v8.iss1.2019.114-120
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