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Abstract

Hair loss problem is of great significance to both men and women. The essential issues associated with hair loss are hair fading, dandruff, and falling of hair. Alopecia is the medical term for hair loss or baldness. It is an embarrassing condition for any person as he/she looks extra aged than ordinary. Many forms of medication are available to treat alopecia in special procedure of medication such as Allopathic, Homeopathic, and Ayurveda or can also be surgical like hair transplantation; however, none of them is wholly ample. This hindrance could be solved by the use of natural medicines obtained from herbs. Terminalia catappa Linn belongs to the family Combretaceae and is popularly known as ‘deshi badam’. It is a well known herb in Ayurvedic system of medicine. Almost all the parts of Terminalia catappa were significantly employed in various ailments. The seed extract of  Terminalia catappa was claimed to have hair growth promotion property. Current study was conducted with an aim to evaluate the hair growth promotion activity of ethanolic seed extract of Terminalia catappa. The extract was mixed in coconut oil, applied on the shaved area of rats and qualitative hair growth analysis was undertaken by observing hair growth initiation time (Minimum time taken to initiate hair growth on denuded skin region), hair growth completion time (Minimum time taken to completely cover the denuded skin region with new hair) and mean hair length were measured. 2% Minoxidil was used as reference control and all the test drugs were applied once daily for 30 days. Ethanolic seed extract of Terminalia catappa significantly decreased the time taken for initiation of hair growth and hair growth completion time. Terminalia catappa significantly increased mean hair length size compared to vehicle treated. From the result it was concluded that Terminalia catappa promotes the hair growth in animal model.

Keywords

Terminalia catappa, Minoxidil Hair growth Promotion and mean hair length

Article Details

How to Cite
Harsha Vardhan K, & Jaikumar S. (2021). Terminalia catappa: A potential herb to promote hair growth, preliminary preclinical study . International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(1), 105-108. https://doi.org/10.61096/ijrpp.v8.iss1.2019.105-108

References

  1. [1]. Banger HS, Malhotra SK, Singh S, Mahajan M. Is early onset androgenic alopecia a marker of metabolic syndrome and carotid artery atherosclerosis in young Indian male patients? Int J Trichology. 7, 2015, 141-147.
  2. [2]. Dharam Kumar KC, Hari Kishan Kumar Y, Neladimmanahally V. Association of androgenetic alopecia with metabolic syndrome: A case–control study on 100 patients in a tertiary care hospital in South India. Indian J Endocrinol Metab. 22(2), 2018, 196-199.
  3. [3]. Libecco JF, Bergfeld WF. Finasteride in the treatment of alopecia. Exp Opin Pharmacother. 5, 2004, 993-940.
  4. [4]. Nadkarni KM. Indian Materia Medica. 4th ed., Vol. 1. Bombay: Popular Prakashn, 1976. p. 1205.
  5. [5]. Masuda T, Yonemori S, Oyama Y, Takeda Y, Tanaka T, Andoh T, Shinohara A, Nakata M. Evaluation of the antioxidant activity of environmental plants: Activity of the leaf extracts from seashore plants. J Agric Food Chem. 47(4), 1999, 1749-1754.
  6. [6]. Lin CC, Chen YL, Lin JM, Ujiie T. Evaluation of the antioxidant and hepatoprotective activity of Terminalia catappa. Am J Chin Med. 25(2), 1997, 153-161.
  7. [7]. Pawar SP, Pal SC, Kasture VS. Anti-inflammatory activity of Terminalia catappa Linn.Pharmacy Focus in the New Millennium Abstracts; 1997. p. 110.
  8. [8]. Ratnasooriya WD, Dharmasiri MG. Effects of Terminalia catappa seeds on sexual behaviour and fertility of male rats. Asian J Androl. 2(3), 2000, 213-219.
  9. [9]. Neelavathi P, Venkatalakshmi P, Brindha P. Antibacterial activities of aqueous and ethanolic extracts of Terminalia catappa leaves and bark against some pathogenic bacteria. Int J Pharm Pharm Sci. 5(1), 2012, 114 120.
  10. [10]. Vijayaprakash S, Langeswaran K, Jagadeesan AJ, Revathy R, Balasubramanian MP. Protective efficacy of Terminalia catappa l. leaves against lead induced nephrotoxicity in experimental rats. Int J Pharm Pharm Sci. 4(Sup 3), 2012, 454-458.
  11. [11]. Tan GT, Pezzuto JM, Kinghorn AD, Hughes SH. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 54(1), 1991, 143-154.
  12. [12]. Teotia S, Singh M. Hypoglycemic effect of Prunus amygdalus seeds in albino rabbits. Indian J Exp Biol. 35(3), 1997, 295-296.
  13. [13]. Eley G. Wild fruits and Nuts. Yorkshire: EP Publishing Ltd.1976.
  14. [14]. Adhirajan N, Dixit V K, Chandrakasan G. Development and Evaluation of Herbal Formulations for Hair growth. Indian Drugs, 2001, 38(11), 559-563.