Main Article Content
Abstract
Diabetes mellitus is a globally prevalent chronic debilitating illness. The goals in management of diabetes are to
alleviate symptoms and signs of hyperglycaemia, and to prevent or reduce the acute and chronic complications of
diabetes. There are a range of oral hypoglycaemic agents available for the treatment of diabetes but they are costly
and have many adverse effects which warrant the continued research for newer drugs. In the present study, the
flower buds of Syzygium aromaticum was studied for its antidiabetic activity against Streptozotocin (55mg/kg, i.p)
induced diabetes in rats. 50% of ethanol was used as solvent to extract the constituents of Syzygium aromaticum
buds. Three dose levels of Syzygium aromaticum (100, 300 and 500mg/kg) were used in the study. The test drugs
were administered once daily for 15 days and the mean body weight, blood sugar were measured on 0, 5, 10 and 15th
day using Glucometer and percentage reduction in blood sugar levels were also determined. All the doses of
ethanolic bud extract of Syzygium aromaticum exhibited antidiabetic effect, but 500mg/kg showed significant
antidiabetic effect as compared to other doses. From the result it was concluded that, Syzygium aromaticum
exhibited antidiabetic effect against Streptozotocin induced diabetes in rats. Further studies are required to establish
its anti-diabetic activity and to find out the exact mechanism for its anti-diabetic effect.
Keywords
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References
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- [2]. Sicree R, Shaw J, Zimmet P. Diabetes and impaired glucose tolerance. Diabetes Atlas. International Diabetes Federation. 5, 2011.
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- [5]. Cai L, Wu CHD. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. J Nat Prod. 56, 1996, 987–990.
- [6]. Niwano Y, Saito K, Yoshizaki F, Kohno M, Ozawa T. Extensive screening for herbal extracts with potent antioxidant properties. J Clin Biochem Nutr. 48(1), 2011, 78-84.
- [7]. Dorenburg A, Page K. The New American Chef: Cooking with the Best Flavors and Techniques from Around the World. John Wiley and Sons Inc. 2003.
- [8]. Gupta S, Kataria M, Murganandan S. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethanopharmacol. 90, 2004, 185–189.
- [9]. Iqra H, Shariq RM, Shahnaz AM, Mudasar N, Khalid G, Bashir AG. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes. 6(4), 2015, 598-612.
References
[1]. Tattersall RB. The History of Diabetes Mellitus: Textbook of Diabetes. Wiley- Blackwell, USA. 4, 2010.
[2]. Sicree R, Shaw J, Zimmet P. Diabetes and impaired glucose tolerance. Diabetes Atlas. International Diabetes Federation. 5, 2011.
[3]. Park K. Diabetes Mellitus. Park‟s Textbook of Preventive and Social Medicine. 21, 2011.
[4]. Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. Springer, USA. 2007.
[5]. Cai L, Wu CHD. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. J Nat Prod. 56, 1996, 987–990.
[6]. Niwano Y, Saito K, Yoshizaki F, Kohno M, Ozawa T. Extensive screening for herbal extracts with potent antioxidant properties. J Clin Biochem Nutr. 48(1), 2011, 78-84.
[7]. Dorenburg A, Page K. The New American Chef: Cooking with the Best Flavors and Techniques from Around the World. John Wiley and Sons Inc. 2003.
[8]. Gupta S, Kataria M, Murganandan S. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethanopharmacol. 90, 2004, 185–189.
[9]. Iqra H, Shariq RM, Shahnaz AM, Mudasar N, Khalid G, Bashir AG. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes. 6(4), 2015, 598-612.