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Abstract
Latest trends have been increasing demand of phyto drugs and some medicinal herbs have proven to be potential in anti-hyper lipedemic activity. Medicinal herbs and extracts are prepared from them are widely used in the treatment of atherosclerosis. The compounds that are responsible for medicinal property of the drug are usually secondary metabolites. The whole plant of Ochna obtusata was collected from Tirumala hills, Tirupati, Andhra Pradesh. India. Ochna is a genus comprising 86 species of evergreen trees, shrubs and shrublets belonging to the family Ochnaceae. The collected whole plant was dried at room temperature, pulverized by a mechanical grinder, sieved through 40 mesh. About 100g of powdered materials were extracted with Ethanol (90%) using soxhlet apparatus. The animals were dosed with the test and the standard drugs orally based on the body weights of the animals. The animals were dosed with the extracts for about 14 days. After this time i.e., 20 hrs after the last application of the test compounds the animals are anaesthetized with anaesthetic ether and 1.2ml of blood is withdrawn by retro orbital puncture. The blood samples will be collected on the 14th day for estimating biochemical parameters.
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References
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- [2]. Y.Rama Rao and B.Venkateswarlu Evaluation of Diuretic Activity of Ethanol Extract of Ochna Obtusata Leaves in Rats Journal of pharmaceutical biology, 3(1), 2013, 14-17.
- [3]. Fowkes FG, Murray GD, Butcher I, et al. Ankle brachial index combined with Framing ham risk score to predict cardio vascular events and mortality: a meta-analysis. JAMA 300(2), 2008, 197–208.
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- [5]. Lederle FA. Management of small abdominal aortic aneurysms. Ann Intern Med 113(10), 1990, 731–2.
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- [7]. Mayfield JA, Reiber GE, Sanders LJ, Janisse D, Pogach LM. Preventive foot care in diabetes. Diabetes Care 27(1S), 2004, S63–4.
- [8]. Rang, Dale, Ritter, Flower, and Henderson: A Text Book of Rang & Dale’s Pharmacology. Elsevier chur chil living stone publishers, 7, 285-293, 604.
- [9]. Ranjan Kumar Giri, Hypolipidemic Activity of Spinacia Oleracea L. in Atherogenic Diet Induced Hyperlipidemic Rats. Journal of Biomedical and Pharmaceutical Research 1(1), 2012, 39-43
- [10]. Shyam Sunder, A.; Rama Narsimha Reddy, A.; Rajeshwar, Y. Kiran, G.; Krishna Prasad, D.; Baburao, B.; Thirumurugu, S.; Karthik, A. Protective effect of methanolic extract of Trianthema portulacastrum in atherosclerotic diet induced renal and hepatic changes in rats. Der Pharmacia. Lettre 2, 2010, 540–545.
- [11]. Wu, Y.; Li, J.; Wang, J.; Si, Q.; Zhang, J.; Jiang, Y.; Chu, L. Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet. Ethnopharmac. 122, 2009, 509–516.
- [12]. Agra, M.F., Franca, P.F., and Barbosa Filho, J.M., Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Braz. J. Pharmacol.17, 2007, 114 -140.
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References
[1]. Humphrey LL, FuR, RogersK, FreemanM, HelfandM. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo ClinProc 83(11), 2008, 1203–12.
[2]. Y.Rama Rao and B.Venkateswarlu Evaluation of Diuretic Activity of Ethanol Extract of Ochna Obtusata Leaves in Rats Journal of pharmaceutical biology, 3(1), 2013, 14-17.
[3]. Fowkes FG, Murray GD, Butcher I, et al. Ankle brachial index combined with Framing ham risk score to predict cardio vascular events and mortality: a meta-analysis. JAMA 300(2), 2008, 197–208.
[4]. FlemingC, WhitlockEP, BeilTL, LederleFA. Screening for abdominal aortic aneurysm: a best- evidence system atic review for the U.S. Preventive Services Task Force. Ann Intern Med 142(3), 2005, 203–11.
[5]. Lederle FA. Management of small abdominal aortic aneurysms. Ann Intern Med 113(10), 1990, 731–2.
[6]. Kent KC, Zwolak RM, Jaff MR, et al. screening for abdominal aortic aneurysm: a consensus statement. J VascSurg 39(1), 2004, 267–9.
[7]. Mayfield JA, Reiber GE, Sanders LJ, Janisse D, Pogach LM. Preventive foot care in diabetes. Diabetes Care 27(1S), 2004, S63–4.
[8]. Rang, Dale, Ritter, Flower, and Henderson: A Text Book of Rang & Dale’s Pharmacology. Elsevier chur chil living stone publishers, 7, 285-293, 604.
[9]. Ranjan Kumar Giri, Hypolipidemic Activity of Spinacia Oleracea L. in Atherogenic Diet Induced Hyperlipidemic Rats. Journal of Biomedical and Pharmaceutical Research 1(1), 2012, 39-43
[10]. Shyam Sunder, A.; Rama Narsimha Reddy, A.; Rajeshwar, Y. Kiran, G.; Krishna Prasad, D.; Baburao, B.; Thirumurugu, S.; Karthik, A. Protective effect of methanolic extract of Trianthema portulacastrum in atherosclerotic diet induced renal and hepatic changes in rats. Der Pharmacia. Lettre 2, 2010, 540–545.
[11]. Wu, Y.; Li, J.; Wang, J.; Si, Q.; Zhang, J.; Jiang, Y.; Chu, L. Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet. Ethnopharmac. 122, 2009, 509–516.
[12]. Agra, M.F., Franca, P.F., and Barbosa Filho, J.M., Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Braz. J. Pharmacol.17, 2007, 114 -140.
[13]. Okigawa, M., Kawano, N., Aquil, M., and Rahman, W.J., Chem. Soc. Perkin Trans. 1, 1976, 580- 583.