Main Article Content

Abstract

The main objective of the present study was to design development and evaluate a press coated pulsatile drug delivery system of captopril for the effective treatment of hypertension. The core was prepared by direct compression using various super disintegrates such as Crospovidone XL 10, Sodium Starch Glycolate and Croscarmellose in different ratios with the drug and chosen the best core formulation. The outer pulsatile coat formulation was prepared by using various polymers such as HPMC K4M, K15M and K100M by varying compression force in terms of ton pressure. The polymers were studied individually and studied the influence of compression force on lag time further obtaining the lag time. All the preliminary studies were evaluated for various post compression parameters along with the dissolution study that was performed using USP paddle method at 50 rpm in 0.1 N HCl and phosphate buffer pH 6.8. The formulation attain a predetermined lag time of 6 h with effective release is selected as the best formulation.

Keywords

Hypertension Captopril Chronopharmaceutics Chronobiology HPMC Crospovidone Lagtime

Article Details

How to Cite
Kannan C, Senthilkumar N, & Thirumurthy R. (2021). Cardiovascular drug delivery: development and characterization of captopril chronomodulated drug delivery system for the management of hypertension. International Journal of Research in Pharmacology & Pharmacotherapeutics, 9(4), 311-326. https://doi.org/10.61096/ijrpp.v9.iss4.2020.311-326