Main Article Content
Abstract
Obesity is a global health problem. It is also known to be a risk factor for the development of metabolic disorders, type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis. In this study we evaluated the ethanolic & aqueous extract of roots of Bauhinia Tomentosa (EEBT & AEBT) for its phytoconstituents & antiobesity activity. The plant material was extracted and subjected to preliminary phytochemical screening. Acute toxicity study was performed to evaluate the toxicity profile. High fat diet was prepared and the treatment schedule was followed for the respective group of animals for 40 days. Daily all the animals were given high fat diet with drug treatment of aqueous and ethanolic root extracts of Bauhinia tomentosa AEBT and EEBT respectively. After 40 days the anti-obesity parameters were evaluated. In preliminary phytochemical analysis, the EEBT & AEBT showed presence of Alkaloids, flavonoids, glycoside sterols, proteins, fixed oils, saponins, tannins. Gums and mucilage, terpenes, steroids, carbohydrates and flavones were absent. The EEBT and AEBT were found to be free from toxicity upto dose of 2000 mg/kg/p.o. Both the extracts at 200 mg/kg and 400 mg/kg significantly reduced body weight, feed intake in the animals. Thereby it could be concluded that Bauhinia tomentosa root extracts exerted significant anti-obese activity