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Abstract
The present study was aimed to study of correlation in between Sublingual Vitamin D3 and Blood Pressure. This
was a non-randomized clinical trial done in collaboration with Department of family and General medicine. All the
known cases of essential hypertension coming to the Family and General Medicine department of PRH, Loni were
enrolled for the study. The study was registered with the Clinical Trial Registry of India (CTRI). Total of 400
patients were enrolled for the study. All the subjects were screened for the serum 25 (OH) D levels. Subjects
fulfilling the eligibility criteria with serum 25 (OH) D levels less than 20 ng/ml, having history of hypertension were
included in the study. At the end of the study, 49 patients (24 from Test and 25 from control group) dropped out of
the study due to their personal reasons and finally 351 patients participated till the end of the study. The subject’s
serum 25(OH) D levels were estimated before and after treatment of sublingual vitamin D3. There was statistically
significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment
with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved role of serum
25(OH)D levels in treatment of Vitamin D3 deficiency patients, whereas in the control group decreased from
baseline 16.40±3.63ng/ml to 14.96±4.94 ng/ml.There was a significant decrease in SBP associated with increasing
25(OH)D levels in response to supplementation. This intervention trail clarified Sublingual Vitamin D3 prevent the
hypertension in the general population