Main Article Content

Abstract

Introduction


 


Antimicrobial-resistance infection is currently one of the main threats to humanity. This study investigates the antimicrobial activity of the different extracts of the Plectranthus coleoides roots that belongs to the Lamiaceae family.


 


Methods


 


100 g of P. coleoides root dried, pulverised extracted with methanol. A further 400 g of the plant content was also macerated successively with n-hexane, ethyl acetate, and methanol. These extracts were evaluated using agar diffusion method for antimicrobial activity on clinical isolates of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans, and minimal inhibitory concentration was determined. Ciprofloxacin has been used as a standard antibacterial drug, while Ketoconazole has been used as a standard antifungal.


 


Results


 


The most active extract on E. coli  has been the ethyl acetate extract with an inhibitory minimum concentration (MIC) of 0.049 mg / mL. Also the n-hexane extract had activity on E. Coli with MIC 0.196 mg / mL. Only n-hexane extract had been successful against Candida albicans with a 6.2 5 mg / mL MIC.


 


Conclusion


 


The n-hexane extract was active against C. albicans, ethyl acetate extract was active against E. coli. Thus, suggesting that the P.coleoides could be of great value in the development of a potent antimicrobial agent with further studies.

Keywords

P.coleoides Ketoconazole C. albicans E. Coli extract n-hexane ethyl acetate

Article Details

How to Cite
Dr. S. K. Devipriya, & Dr. V. Sathyanathan. (2021). Evaluation of antimicrobial activity of the roots of Plectranthus Sp. International Journal of Research in Pharmacology & Pharmacotherapeutics, 9(4), 269-273. https://doi.org/10.61096/ijrpp.v9.iss4.2020.269-273