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May 9, 2023
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May 9, 2023
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Abstract

The formulation of only moderately water-soluble pharmaceuticals can benefit from the incorporation of nanoparticles, which increases the drugs’ bioavailability. The primary objective of this work was to create and evaluate Itraconazole-loaded nanoparticles using the ionic gelation process to improve their solubility and bioavailability. Ionic gelation was used to prepare Itraconazole nanoparticles, which are classified as a BCS class II drug. These particles were then characterized using techniques such as Fourier transform infrared spectroscopy, differential scanning Calorimetry, powder X-ray diffraction, scanning electron microscopy, zeta potential, and in-vitro drug release studies.There was no evidence of contact between the drug and the polymers based on the differential scanning Calorimetry results, powder X-ray diffractometry, and Fourier transforms infrared spectroscopy. Images obtained by scanning electron microscopy revealed that the nanoparticles had a spherical form.Nanoparticulate formulation prepared with Chitosan in 1:6 ratio showed satisfactory results i.e. average particle size 201.67 nm, polydispersity index 0.111, zeta potential -46.2 mV, and entrapment efficiency 89.04%. FTIR study concluded that no major interaction occurred between the drug and polymers used in the present study.This technology on a laboratory scale and this strategy could be used to improve the solubility and bioavailability of BCS class II medications.

Keywords

Itraconazole, ionic gelationmethod, Chitosan,BCS class II drug, Bioavailability, Dissolution and Nanoparticles.

Article Details

How to Cite
Krishnendu Sahoo, Mithun Bhowmick, Tulshi Chakraborty, Sudip Roy, & Pratibha Bhowmick. (2023). Formulation and evaluation of polymeric nanoparticles of itraconazole for antifungal therapy. International Journal of Research in Pharmacology & Pharmacotherapeutics, 12(2), 107-116. https://doi.org/10.61096/ijrpp.v12.iss2.2023.107-116
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