@article{Krishnendu Sahoo_Mithun Bhowmick_Tulshi Chakraborty_Sudip Roy_Pratibha Bhowmick_2023, title={Formulation and evaluation of polymeric nanoparticles of itraconazole for antifungal therapy}, volume={12}, url={https://ijrpp.com/ijrpp/article/view/475}, DOI={10.61096/ijrpp.v12.iss2.2023.107-116}, abstractNote={<p>The formulation of only moderately water-soluble pharmaceuticals can benefit from the incorporation of nanoparticles, which increases the drugs’ bioavailability. The primary objective of this work was to create and evaluate Itraconazole-loaded nanoparticles using the ionic gelation process to improve their solubility and bioavailability. Ionic gelation was used to prepare Itraconazole nanoparticles, which are classified as a BCS class II drug. These particles were then characterized using techniques such as Fourier transform infrared spectroscopy, differential scanning Calorimetry, powder X-ray diffraction, scanning electron microscopy, zeta potential, and <em>in-vitro</em> drug release studies.There was no evidence of contact between the drug and the polymers based on the differential scanning Calorimetry results, powder X-ray diffractometry, and Fourier transforms infrared spectroscopy. Images obtained by scanning electron microscopy revealed that the nanoparticles had a spherical form.Nanoparticulate formulation prepared with Chitosan in 1:6 ratio showed satisfactory results i.e. average particle size 201.67 nm, polydispersity index 0.111, zeta potential -46.2 mV, and entrapment efficiency 89.04%. FTIR study concluded that no major interaction occurred between the drug and polymers used in the present study.This technology on a laboratory scale and this strategy could be used to improve the solubility and bioavailability of BCS class II medications.</p&gt;}, number={2}, journal={International Journal of Research in Pharmacology & Pharmacotherapeutics}, author={Krishnendu Sahoo and Mithun Bhowmick and Tulshi Chakraborty and Sudip Roy and Pratibha Bhowmick}, year={2023}, month={May}, pages={107-116} }