Main Article Content

Abstract

A series of piperidine-4-carboxylic acid methyl ester coupled with N-phthaloyl amino acids derivatives were synthesized, characterized and their antimicrobial properties were evaluated. These compounds were synthesized with dicyclohexylcarbodimide coupling of piperidine-4-carboxylic acid methyl ester with N-phthaloyl amino acids with N, N'-dicyclohexylcarbodiimide followed by ring opening reaction with cyclopropylamine and reaction of ester with hydrazine hydrate to obtain final compound characterized using IR, 1H and 13C-NMR and mass spectroscopy. The synthesized compounds were screened for their in vitro antimicrobial activity against S. aurous, E. coli, P. aeruginosa, S. typhimurium, F. oxysporum and A. alternate. Some of these compounds exhibited moderate to good activity, where as some were inactive.

Keywords

N-phthaloyl amino acids Cyclopropylamine Antimicrobial activity DCC Coupling Hydrazine hydrate

Article Details

How to Cite
Paresh Shende, Kartik Vyas, & Dr. Kaushik Joshi. (2021). A work on synthesis & characterization of Piperidine-4-carbohydrazide derivatives with its antimicrobial evaluation of pharmaceutical interest. International Journal of Research in Pharmacology & Pharmacotherapeutics, 5(3), 262-272. Retrieved from https://ijrpp.com/ijrpp/article/view/362

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