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May 26, 2021
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May 26, 2021
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Abstract

Aim of the study


To evaluate the neuroprotective activity of ethanolic extract of seeds of Peganum harmala (PHEE) in wistar rat.


Materials and methods


Ethanolic extract of seeds of Peganum harmala was screened for anti-Parkinson's effect by using behavioral method, haloperidol induced catalepsy at a dose of 50 mg/kg and 100 mg/kg. Distilled water and L-dopa were employed as control and standard groups respectively.


Results


Peganum harmala at a dose of 100 mg/kg showed maximal decrease in catalepsy (71±4.0 at 60 Minute) as compared to both negative and positive control groups.


Conclusion


Ethanolic extract of seeds of Peganum harmala may be useful in Parkinson's disease.

Keywords

Parkinson's disease Haloperidol Peganum harmala L-dopa

Article Details

How to Cite
Abdulrahman M. Alshahrani. (2021). Evaluation of anti-Parkinson’s effect of Peganum harmala on haloperidol induced catalepsy in experimental animal model . International Journal of Research in Pharmacology & Pharmacotherapeutics, 5(3), 245-250. https://doi.org/10.61096/ijrpp.v5.iss3.2016.245-250
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