Antidiabetic activity of alcoholic fruit extract of mallotus philippensis muell.arg. in streptozotocin induced diabetic rats

Abstract

Herbal drugs are frequently considered to be less toxic and also free from side effects, than synthetic ones. In the present work the antidiabetic activity of the Mallotus philippensis was evaluated. The alcoholic fruit extract showed significant decrease in blood glucose level, glycosylated haemoglobin level and significant increase in plasma insulin level when administered orally for 21 days to STZ induced diabetic rats at a dose of 200 and 400 mg/kg. The extract showed significant decrease in serum parameters such as total cholesterol level, ALT and AST levels. In antioxidant study, the extract showed significant activities in both enzymic antioxidant parameters like SOD, CAT, GPx and non ezymic antioxidant parameters like GSH, Vit C, Vit E. These results demonstrate the antidiabetic potential of alcoholic fruit extracts of Mallotus philippensis and suggests that M.philippensis fruit may have the therapeutic value in diabetes and related complications.