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May 10, 2021
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May 10, 2021
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Abstract

Background


Pain is a very unpleasant sensory and emotional experience due to tissue damage. There are many effective analgesics available, which are widely used to reduce pain, but they are associated with many side effects which limit their clinical use. Therefore, in this study we aim to demonstrate the analgesic activity of Ferula Asafoetida at three different doses in animal model.


Materials and Methods


The animals were divided into their respective groups of 6 mice each. Central Analgesic activity of Ferula Asafoetida aqueous extract at three different dose (5mg/kg, 10mg/kg, 20mg/kg) was assessed by hot plate method in mice. Difference in mean change in reaction time was calculated for each group and was compared with tramadol. Peripheral analgesic activity was assessed by acetic acid induced writhing in mice. Mean number of wriths was calculated and it was compared with diclofenac. Statistical analysis was done by ANOVA followed by Dunnett’s t-test and p <0.05 was considered significant.


Results


In the hot plate method, central analgesic activity of Ferula Asafoetida at a dose of 20mg/kg was statistically comparable to Tramadol at different time points (20min, 60 min, 90 min). Though there was a significant increase in reaction time of Ferula asafetida group at a dose of 10mg/kg when compared to control but was not statistically comparable to tramadol. In acetic acid induced writhing method, peripheral analgesic activity of Ferula asafetida at a dose of 20mg/kg was significantly comparable to diclofenac.


Conclusion


In this study it was concluded that Ferula Asafoetida has significant central as well as peripheral analgesic activity as compared to standard treatments i.e; Tramadol and Diclofenac respectively.

Keywords

Ferula Asafoetida Hot Plate Acetic acid induced writhing Cyclo-oxygenase

Article Details

How to Cite
Hasan.R, Abidi.A, Qadeer.F, Rizvi.D, Thadani.A, & Arora.S. (2021). Demonstration of analgesic activity of ferula asafoetidain an animal model. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(4), 381-389. https://doi.org/10.61096/ijrpp.v7.iss4.2018.381-389
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