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May 10, 2021
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May 10, 2021
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Abstract

Aim and Objectives


This study is aimed to screen the anti-cancer action of naringenin in 7, 12-dimethyl benzanthracene induced breast cancer in female Wistar albino rats.


Materials and Methods


The study was conducted in the Division of Pharmacology, Annamalai University, Tamil Nadu. Female Wistar Albino rats weighing 140-150gm were selected in this study. All the animals were kept in Central Animal House under standard conditions. Total 36 rats were divided into six groups, each of 6 rats. G-I (Control), G-II- (7,12-Dimethyl benzanthracene (25 mg/kg/BW/sc), G-III (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Vincristine (500 µg/kg/BW/ip), G-IV (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (50 mg/kg/BW/PO), G-V (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (100 mg/kg/BW/PO) and G-VI (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (200 mg/kg/BW/PO). Inducing drug was administered only once. All the drugs were given upto 16 weeks and blood samples were collected to estimate the anti-oxidant enzymes like TBARS, Super oxide dismutase, Catalase, Glutathione and Glutathione peroxidase.


Results


Group-II showed significant changes compared to group-I. Group-III and V showed significant difference compared to Group-II. Group-V did not show significant difference compared to Group-III in TBARS, super oxide disumutase, catalse, glutathione and glutathione peroxidase enzymes.


Conclusion


Naringenin (100 mg/kg/BW/) showed significant anti-cancer effect compared to other doses.

Keywords

Anti-cancer Anti-oxidants Naringenin vincristine 7, 12-Dimethyl bensanthracene Plasma

Article Details

How to Cite
Sandeep V M, Nirmala P, & SarathBabu K. (2021). Screening of anti-cancer effect of naringenin in 7, 12-dimethyl benzanthracene induced breast cancer in female Wistar Albino rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(4), 375-380. https://doi.org/10.61096/ijrpp.v7.iss4.2018.375-380
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