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Abstract

Nephrotoxicity is one of the important side effects of Cisplatin. The aim of the study was to determine the protective effect of Tamarindus indica Linn fruit pulp extract on Cisplatin induced nephrotoxicity in rats using biochemical approaches. The experiment was done in Cisplatin-induced acute renal failure in Albino wistar rats. Thirty rats were divided into five groups. Group 1 was given Dimethyl sulphoxide (DMSO) (5 ml/kg) per oral, group 2 with single dose of Cisplatin (7.5 mg/kg) by intra peritoneal injection into the peritoneal cavity, group 3 with Cisplatin and standard nephroprotective drug Lipoic acid (50 mg/kg) orally, group 4, with Cisplatin and ethanolic extract of Tamarindus indica Linn fruit pulp extract (EETI) 200 mg/kg and group 5, Cisplatin and EETI 400 mg/kg. Extract and standard drug Lipoic acid were given orally 120 min prior to Cisplatin injection. 24 h urine output, Animal body weight, serum creatinine, serum blood urea nitrogen and Creatinine clearence were measured for all the groups. Kidneys were examined for histopathological changes. The antioxidant activity of the extract was tested in vivo. Rats treated with EETI showed significant improvement in biochemical parameters and histopathological changes compared to Cisplatin treated group. The protective effect was highly significant at 400 mg/kg. The in vivo assays showed significant antioxidant activity. The EETI has nephroprotective effect in Cisplatin-induced acute renal failure

Keywords

Nephrotoxicity , Tamarindus indica Linn Fruit extract Cisplatin

Article Details

How to Cite
G. Sumithira, Danish T.K, Muhammed Shabeer A, Muhammed Anas K, & Krishnamoorthy.B. (2021). Nephroprotective activity of tamarindus indica linn fruit extract on cisplatin induced nephrotoxicity in rats. International Journal of Research in Pharmacology & Pharmacotherapeutics, 9(2), 153-165. https://doi.org/10.61096/ijrpp.v9.iss2.2020.153-165