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Proton pump inhibitors (PPI's) remain the superior choice worldwide in antisecretory therapy in the evidence-based treatment of upper gastrointestinal disorders including gastroesophageal reflux disease, erosive esophagitis, dyspepsia and peptic ulcer disease. Nonjudicious use of PPIs creates both preventable financial as well as medical concerns. PPIs have been associated with an increased risk of vitamin and mineral deficiencies.


To study the effect of Proton Pump Inhibitors (PPI’s) effect on vitamin D levels.


A study To evaluate the effect of PPI's on vitamin D levels in patients who were treated for vitamin D deficiency.


February 2017 to July 2017.



One hundred patients treated for vitamin D deficiency at


100 patients were included in the study. 40 patients were taking PPI at the time and during the study. 60 patients were not on any medications. Results were assessed by improvement in repeat serum 25(OH) vitamin D levels obtained after replacement therapy. Demographics, vitamin D levels, medical history and medication lists were obtained. Percentage increase in 25‐OH vitamin D levels from baseline was considered the end point. Results were compared between the two groups. Statistics include unpaired t-test done to compare two groups of subjects and p value less than 0.05 was considered statistically significant.


The mean improvement in 25(OH) vitamin D levels for the “PPI” group was 40.9% with a mean raw difference of 9.1. “No PPI” group demonstrated a mean improvement of 59.1 % with a mean difference of 13.8. The improvement in 25(OH) vitamin D levels in the "no PPI" cohort was 64.2% greater than those taking a PPI.


PPIs are associated with an increased risk of vitamin D deficiency impacting vitamin D metabolism.


Proton Pump Inhibitors (PPI’s) Vitamin D Metabloism

Article Details

How to Cite
Dr. Syed Arshaduddin Ahmed, & Dr. P. Srujana. (2021). A study to evaluate the effect of proton pump inhibitors (PPI’S) on vitamin d levels. International Journal of Research in Pharmacology & Pharmacotherapeutics, 7(4), 320-326. Retrieved from


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