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Abstract
The goal of this study was to investigate the effect of Tecomastansethanolic extract (EETS) on the psychosis induced by MK‐801 in mice. MK‐801-treated mice were administered for 14 days using EETS (1 and 2 g / kg, p.o.) Specific behavioral parameters and neurochemical measures such as dopamine (DA), 5‐hydroxytryptamine (5‐HT), norepinephrine (NE), gamma-aminobutyric acid (GABA), glutamate, and glycine were assessed as well as indicators of oxidative stress such as nitrite rates.
Psychosis-induced mice showed a significant increase in immobility time in forced swimming test, locomotive operation, and decrease in durability in rota-rod testing, escape latency time in Cook's pole test while EETS treatment showed a significant improvement in the above-mentioned behavioral parameters in psychosis induced by MK-801. In addition, psychosis caused by MK‐801 in mice showed a substantial increase in DA, 5‐HT and NA levels and a decrease in brain GABA, glutamate, and glycine levels. In comparison, EETS therapy at both doses greatly altered the parameters of neurochemistry. Additionally, EETS treated mice showed a substantial reduction in EETS acetylcholinesterase, D‐amino acid oxidase enzyme activity, and the levels of nitrite elevated by MK‐801 administration. Via neuromodulation and reduced oxidative stress, EETS therapy once for 14 days (1 and 2 g / kg) substantially improved behavioral symptoms in experimentally induced psychosis.