Analgesic, anti-inflammatory & CNS depressant activity of methanolic extract of plectranthus vettiveroides stem bark in mice

Abstract

Objectives

This study was conducted to evaluate the analgesic, anti-inflammatory, and central nervous system inhibitory activities of the methanol extract of mouse Platycladus orientalis (MEPV).

Materials and methods

The analgesic activity of MEPV was evaluated by formalin-induced licking and at biting mice with doses of 200 mg/kg and 400 mg/kg body weight. By using the carrageenan-induced inflammation method, the anti-inflammatory effects of MEPV were studied here at doses of 150 mg/kg body weight and 300 mg/kg body weight. CNS inhibitory activity has been measured by generally observing a reduction in exercise doses between 200 and 400 mg/kg body weight in the hole cross assessment.          

Results

Statistical analysis showed that compared with diclofenac sodium (79.34%), the 400 mg/kg dose exhibited licking protection (87.30%) in addition to biting formalin-induced rodents in the later stages. Compared with the standard diclofenac sodium (15.94% and 17.48%), the 150 mg/kg dose showed sustained suppression (17.26% and 22.95%) of paw edema at the 3rd and 4th hours. In addition, compared with ordinary diclofenac sodium, the 300 mg/kg dose caused a higher percentage of sustained inhibition of paw edema per hour per hour. In addition, the extract also had a considerable (p <0.05) dose-dependent CNS inhibitory activity.

Conclusion

Current study recommends that this methanolic extract of Plectranthus vettiveroides stem bark has important analgesic, anti-inflammatory and CNS depressant properties