Main Article Content
Abstract
Background
Constant itching and inflammation due to fungal infection in a diabetic patient leads to stress, causing epinephrine to release which may cause change in blood glucose level mostly, results in hyperglycemia. Long term antifungal medication like azoles shows changes in blood glucose level which could be beneficial to diabetic patient. In the above context to see the probability, we conducted this study.
Aim
To study the effect of azoles (antifungal drugs) on blood glucose level in albino rabbits.
Material &method
Healthy male albino rabbits were taken and randomly distributed into groups and each group contain six rabbits(n=6).Rabbits in group I were treated with normal saline, group II rabbits were treated with insulin, group III rabbits with Glibenclamide, fourth group were treated with Fluconazole, Vth group with Itraconazole and group VI with Ketoconazole. Blood samples were collected before drug administration (0 hr.) and after administration of drug at 1hr, 2hr, 4th hr, 6th hr, and on 10th day. In case of insulin treated rabbits half an hour samples were also collected. The blood glucose levels were determined by GOD/POD method.
Result
Fluconazole and Itraconazole do not show any significant effect (p>0.05) on blood glucose level in albino rabbits. While ketoconazole has insignificant effect (p>0.05) on blood glucose level at one hour but significant effect at 2ndhr (p<0.001) and 4th hr (p<0.001). 6th hr blood glucose level is same as that of 1 hr (p>0.05) and 10th day hypoglycemic effect (after 4 hr of drug administration) is almost similar to hypoglycemic effect observed by ketoconazole at 4th hr on 1st day. Ketoconazole induced hypoglycemia is approximately similar to Glibenclamide induced hypoglycemia at 2ndhr and 4thhr.
Conclusion
No significant effect with Fluconazole and Itraconazole but significant short term hypoglycemic effect with Ketoconazole. Watchful need should be taken in diabetic patient who are on hypoglycemic drugs.