Main Article Content
Abstract
Kanaka lingakarpoorathimezhugu is a herbomineral drug preparation used in Siddha system of medicine used to treat thyroid disorders and allied ailments. Known risk factors for thyroid disease include autoimmunity, external irradiation of the head and neck, a biosynthetic defect in iodine organification, replacement of the thyroid gland by tumour, and use of certain drugs. There are several forms of herbomineral drugs like Mezhugu, Parpam, Chendooram, Chunnam, Pathangam, Kattu, Kalanguetc have their in own pharmacological system, but needs to meet the global standards. Male albino rats of were used for this present thyro-toxicity study. Animals were provided with normal rats feed and normal water ad libitum. Hypothyoidi condition was induced using methimazole. They were provided with KLK mezhugu in water suspension in test groups. Aanimals were sacrificed, blood was drawn and the serum was separated for biochemical analysis. The result of this study shows the significant thyrotoxicity induced by methimazole was evidenced by increase in serum T3 Triiodothyronine, T4 Thyroxine, TSH secretion due to thyroid cellular necrosis. The administration of KLK mezhugu for 30 days was found able to treat and protect thyroid necrosis against methimazole induced thyroid-toxicity.
Keywords
Article Details
References
- [1]. Canaris GJ, Manowitz NR, Mayor G. The Colorado thyroid disease prevalence study. ArchIntern Med, 160(4), 2000, 526–534.
- [2]. Baskin HJ, Cobin RH, Duick DS. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. EndocrPract, 8(6), 2002,457–469.
- [3]. Delange F. Endemic cretinism. In: Braverman L, Utiger R, eds. The Thyroid. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2000, 743–754.
- [4]. Singer P. Primary hypothyroidism due to other causes. In: Braverman L, Utiger R, eds. The Thyroid. Philadelphia, PA: Lippincott Williams & Wilkins, 8, 2000, 755–761.
- [5]. Friedman and Young. Effects of disease on clinical laboratory tests, AACC Press, 4, 2001.
- [6]. Reitman. Sand S Frankel..Am J Clinpathol., 28, 1957, 56-63.
- [7]. Fisher.A., in statistical methods for research worker.Oliver and boyed , Edinburgh. 1950.
- [8]. Nakamura H, Noh JY, Hoh K, Fukata S, Miyauchi A, Hamada N. Comparision of methimazole and propyl thio uracil in patients with hyperthyroidism caused by grave’s disease. The journal of clinical Endocrinology and metabolism. 92(6), 2007, 2157-62.
- [9]. Wrutniak-Cabello C, Casas F, Cabello G. Thyroid hormone action in mitochondria. Journal of Molecular Endocrinology. 26, 2001, 67–77.
- [10]. Brian Kim. Thyroid Hormone as a Determinant of Energy Expenditure and the Basal Metabolic Rate.Thyroid.18(2), 2008, 141-144. doi:10.1089/thy.2007.0266.
References
[1]. Canaris GJ, Manowitz NR, Mayor G. The Colorado thyroid disease prevalence study. ArchIntern Med, 160(4), 2000, 526–534.
[2]. Baskin HJ, Cobin RH, Duick DS. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. EndocrPract, 8(6), 2002,457–469.
[3]. Delange F. Endemic cretinism. In: Braverman L, Utiger R, eds. The Thyroid. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2000, 743–754.
[4]. Singer P. Primary hypothyroidism due to other causes. In: Braverman L, Utiger R, eds. The Thyroid. Philadelphia, PA: Lippincott Williams & Wilkins, 8, 2000, 755–761.
[5]. Friedman and Young. Effects of disease on clinical laboratory tests, AACC Press, 4, 2001.
[6]. Reitman. Sand S Frankel..Am J Clinpathol., 28, 1957, 56-63.
[7]. Fisher.A., in statistical methods for research worker.Oliver and boyed , Edinburgh. 1950.
[8]. Nakamura H, Noh JY, Hoh K, Fukata S, Miyauchi A, Hamada N. Comparision of methimazole and propyl thio uracil in patients with hyperthyroidism caused by grave’s disease. The journal of clinical Endocrinology and metabolism. 92(6), 2007, 2157-62.
[9]. Wrutniak-Cabello C, Casas F, Cabello G. Thyroid hormone action in mitochondria. Journal of Molecular Endocrinology. 26, 2001, 67–77.
[10]. Brian Kim. Thyroid Hormone as a Determinant of Energy Expenditure and the Basal Metabolic Rate.Thyroid.18(2), 2008, 141-144. doi:10.1089/thy.2007.0266.