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Abstract
Erythrina variegate Lam commonly known as Indian Coral tree, belonging to the family Fabaceae. It contains about 130 species, which are distributed in tropical and sub tropical regions worldwide. Various parts of the plants such as bark, root, stem, leaves, fruits and flowers possess many medicinal values, particularly for treating fever, liver ailments, rheumatism, relieve joint pain, kills the worms etc. The preliminary phytochemical screening of Ethanolic extract of Erythrina variegate (EEEV) was carried out and revealed the presence of flavonoids, alkaloids, glycosides, carbohydrates, steroids, saponins and triterpenoids. The aim of the work is to assessed the cytotoxic activity of the EEEV by the hemolytic test and the Isolated Chicken Eye (ICE) test. The cytotoxic effect was found to be negative towards the corneal cells and the human blood cells.
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References
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References
[1]. Pocket Guide to Herbal Medicine. Karin Kraft, M. D., Christopher Hobbs, L. Ac. P. No: 1.
[2]. Selected Medicinal plants of Chittagong hill tracts. Published by IUCN, 1-3.
[3]. Heged N. Cultivation and uses of Erythrina variegate in Western India. In: Westley SB, Powell MH (eds.), Erythrina in the New old Worlds Palahi, USA; MC Graw-Hill, 1993; 77-84.
[4]. Mangathayaru K, Sarah K, Balakrishna K. Estrogenic effect of Erythrinavariegate L. in the Prepubertal female rat. Indian J Nat Prod Resour 5, 2014, 223- 7.
[5]. Ghani A. Medicinal plants of Bangladesh with chemical constituents and uses. 2nd Edition, Bangladesh, Asiatic society; 2003, 222-223
[6]. James HR, Christopher D. Synthetic studies on the Erythrina alkaloids preparation of 2- epi- erythrinitol. Tetra Hedron letters, 63, 1999, 6887- 6890.
[7]. RangariV.d. 2002 Pharmacognosy and Phytochemistry, 1, 103-105.
[8]. RangariV.d. 2002 Pharmacognosy and Phytochemistry, 1, 66-74.
[9]. https://www.cyprotex.com/toxicology/mechanistic-toxicity/hemolysis
[10]. oecd-ilibrary.org/environment/test-no-438-isolated-chicken-eye-test-method-foridentifying-i-chemicals-inducing-serious-eye-damage-and-ii-chemicals-not-requiring-classification-for-eye-irritation-or-serious-eye-damage9789264203860-en
[11]. https://www.nelsonlabs.com/testing/hemocompatibility/
[12]. Sharma, P.; Sharma, J.D. In vitro hemolysis of human erythrocytes by plant extracts with antiplasmodial activity. J. Ethnopharmacol.74, 2001, 239–243
[13]. Feng B, Xu JJ, Bi YA, Mireles R, Davidson R, Duignan DB, Campbell S, Kostrubsky VE, Dunn MC, Smith AR, Wang HF, ToxicolSci 108, 2009, 492-500.