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The term epilepsy is derived from the Greek word epilam-banein, meaning to attack or seize. People once thought that epileptic individuals were being visited by demons or gods. However, in 400 b.c., the early physician Hippocrates suggested that epilepsy was a disorder of the brain—and he was right.

Materials and Methods

In the laboratory procedures have been developed in which epileptic activity is closely approximated. The procedures used in this study are Electrical Methods and Chemical Methods. In the present studies all the anticonvulsants were administered intraperitoneally and their peak effect was determined prior to the evaluation of their potencies against electroseizures and chemical seizures.


The peak anticonvulsant effect of Diazepam and Nitrazepam is 2 hours after intraperitoneal injection whereas for Phenobarbitone it was stretched from 2nd hour to 3rd hour.


The time of peak effect of phenobarbitone in mice on intraperitoneal administration was ranging from 2nd hour to 3rd hour whereas for diazepam and nitrazepam it was 2nd hour. 0.5 mg/kg of nitrazepam was equipotent to 60 mg/kg of phenobarbitone which in turn was roughly equivalent to 0.5 mg/kg of diazepam.


Epilepsy Phenobarbitone Diazepam Nitrazepam Electrical Methods Chemical Methods

Article Details

How to Cite
Dr G N S Sangeetha Lakshmi, & Dr U Bharathi. MD. (2021). Anticonvulsant effects of diazepam and nitrazepam in mice. International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(3), 348-357.


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