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Apr 11, 2021
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Apr 11, 2021
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Abstract

Background


Metabolic Syndrome is a constellation of cardio metabolic abnormalities such as central obesity, dyslipidemia, hyperglycemia, hypertension, proinflammatory and prothrombotic state. Dyslipidemia is one of the important components of this syndrome and also important risk factor for cardiovascular disease. Statins are used as first line drugs for dyslipidemia but right now several drugs are available in Indian market and it is difficult for medical practitioners to select a suitable one among them. This is a study to evaluate the efficacy and safety of most commonly used atorvastatin with rosuvastatin in patients with metabolic syndrome.


Objectives


To compare the efficacy and safety of Rosuvastatin and Atorvastatin in patients with metabolic syndrome.


Methods


A total of 60 subjects diagnosed with Metabolic syndrome were included in the study. They were randomized into two groups, the first group received, Rosuvastatin 10mg and second group received Atorvastatin 10 mg for 6 weeks. Lipid profile was evaluated for efficacy; liver function tests (LFT) and serum creatine for safety. Adverse effects were evaluated based on symptomatology and laboratory parameters.


Results


Both the groups showed significant improvement in lipid profile, seen by reduction in LDL, Triglycerides, total cholesterol and increase in HDL levels compared to baseline values (p<0.001). Intergroup comparison showed that 10mg of Rosuvastatin was better in providing a favourable lipid profile compared to 10mg of Atorvastatin. Changes in LFT and serum creatine were not significant statistically both within and between the groups.


Conclusion


Rosuvastatin was found to be better than atorvastatin in providing a favourable lipid profile for patients with metabolic syndrome and both the drugs were well tolerated and safe.

Keywords

Metabolic syndrome dyslipidemia atorvastatin rosuvastatin

Article Details

How to Cite
Dr Sushma H K, & Dr Jyothi C H. (2021). Comparative study on efficacy and safety of Rosuvastatin v/s Atorvastatin in patients with metabolic syndrome- a prospective observational study. International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(3), 326-334. https://doi.org/10.61096/ijrpp.v8.iss3.2019.326-334
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