Review on Pulsatile Drug Delivery System

Abstract

The Pulsatile Drug Delivery System (PDDS) is a novel drug delivery approach designed to release drugs at specific time intervals, mimicking the body’s natural biological rhythms. Unlike conventional controlled or sustained release systems, pulsatile delivery provides a rapid and complete release of the drug after a predetermined lag time. This system is particularly beneficial for the treatment of diseases that follow circadian rhythms, such as asthma, cardiovascular disorders, arthritis, diabetes, and peptic ulcer disease.

Pulsatile drug delivery systems are useful for drugs with short biological half-lives, extensive first-pass metabolism, or those that may cause tolerance when administered continuously. Various techniques, including time-controlled, stimulus-responsive (pH, temperature, enzyme, or glucose sensitive), and externally regulated systems, are employed to achieve pulsatile drug release. The use of specialized polymers and advanced formulation strategies enables precise control over drug release timing. Overall, pulsatile drug delivery systems improve therapeutic efficacy, reduce side effects, and enhance patient compliance by delivering drugs only when needed. This targeted and chrono therapeutic approach represents a promising advancement in pharmaceutical drug delivery technology.