Main Article Content

Abstract

Background


Tuberculosis and HIV infections are the major health problems, especially in rural areas like Perambalur. Tuberculosis kills 1.8 million people per year worldwide. Unsuccessful treatment programmes for disease control and continued transmission are contributing to the emergence and spread of multidrug-resistant (MDR) tuberculosis (i.e., bacillary resistance to at least rifampicin and isoniazid). The spread of HIV infection has produced new challenges in the diagnosis and treatment of tuberculosis.


Methods


 A retrospective study was conducted among 836 patients with the help of a proforma that consists of relevant details of patient taken from the treatment card. The data was collected among people who were pulmonary tuberculosis positive within the period of two years from January 2015 to December 2016.


Results


 Among these pulmonary TB positive patients, 94 were found to be co-infected with HIV infection as per the data collected from District Head Quarters Hospital, Perambalur. The prevalence of TB with HIV co-infection was about 11.2%. These patients were presented with various atypical clinical presentations. 97% of pulmonary TB co-infected with HIV with these atypical presentations belongs to younger age group (10 to 27). The age group were majority of co-infection was between 30 to 40 years. The prevalence of co-infection has been reduced as compared to previous years, due to effective and supportive measures.

Keywords

Tuberculosis TB – HIV co-infection rural areas tuberculosis Prevalence HIV status

Article Details

How to Cite
R.Nivetha, & Dr. M. Saravana Kumar M.D. (2021). To find the prevalence of HIV infection in pulmonary tuberculosis patients admitted in a secondary and tertiary care hospital of a rural area in Tamilnadu – A retrospective study. International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(2), 247-257. https://doi.org/10.61096/ijrpp.v8.iss2.2019.247-257

References

  1. [1]. Murray CJL, Styblo K, Rouillon A. Tuberculosis in developing countries: burden, intervention and cost. Bull Int Union Tuberc Lung Dis 65, 1990, 6-24
  2. [2]. SelwynPA, Hartel D, Lewis VA, Schoenbaum EE, Vermund SH, Klein RS et al. A prospective study of the risk of tuberculosis among intravenous drug users with human immunodeficiency virus infection. N Engl J Med; 320, 1989, 545-50.
  3. [3]. Bermejo A,Veeken H, Berra A. Tuberculosis incidence in developing countries with high prevalence of HIV infection. AIDS 6, 1992, 1203-6.
  4. [4]. Chaisson RE, Schecter GF, Theuer CP, Rutherford GW, Echenberg DF, Hopewell PC. Tuberculosis in patients with the acquired immunodeficiency syndrome: clinical features, response to therapy and survival. Am Rev Respir Dis: 136, 1987, 5
  5. [5]. Pitchenik AE, Rubinson HA. The radiographic appearance of tuberculosis in patients with the acquired immune deficiency syndrome (AIDS) and pre AIDS. Am Rev Respir Dis; 131, 1985, 393-6.
  6. [6]. Corbett EL, Marston B, Churchyard GJ, De Cock KM. TuberculosisIn sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment. Lancet 367, 2006, 926–37.
  7. [7]. Maartens G, Wilkinson RJ. Tuberculosis. Lancet 2007.
  8. [8]. Kumar and clark’s , seventh edition, 4, 204.
  9. [9]. Interim policy on collaborative TB/HIV activities, 1st ed. Geneva, World Health Organization, 2004
  10. [10]. Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosisM. Cristina Gutierrez, Sylvain Brisse, Roland Brosch, Michel Fabre, Bahia Omaïs, MagaliMarmiesse, Philip Supply, Veronique Vince
  11. [11]. Tuberculosis, A Comprehensive Clinical Reference, 1e, Edition one. Edited by H.SimonSchaaf, Alimuddin I. Zumla Chapter 12, and 119.
  12. [12]. Tuberculosis, A Comprehensive Clinical Reference, 1e, Edition one. Edited by H. Simon Schaaf, Alimuddin I. Zumla 12, 122.
  13. [13]. Snider Jar DE, LaMontagne JR. The neglected global tuberculosis problem; a report of the 1992 World Congress on Tuberculosis. J Infect Dis: 169, 1994, 1189-96.
  14. [14]. Microbiol Rev. 1993 Mar; 57(1): 183–289.PMCID: PMC372905 Pathogenesis of human immunodeficiency virus infection. J A Levy
  15. [15]. Tuberculosis and Human Immune Deficiency Virus Co-infection in DebreMarkos Referral Hospital in Northwest Ethiopia: A Five Years Retrospective Study.
  16. [16]. Kanai K, Kurata T, Akksilp S, Auwanit W, Chaowagul V, Naigowit P. A preliminary survey for human immunodeficiency virus (HIV) infections in tuberculosis and melioidosis patients in UbonRatchanthani, Thailand.Jpn J Med SciBiol: 45, 1992, 247-53.
  17. [17]. Rosenblum LS, Castro KG, Dooley S, Morgan M. Effect of HIV infection and tuberculosis on hospitalizations and cost of care for young adults in the United States, 1985 to 1990. Ann Intern Med; 121, 1994, 786-92.
  18. [18]. Talib SH, Bansal MD, Kumble MM. HIV-1 seropositivity in pulmonary tuberculosis (A study of 340 cases from Marathawada). Indian J PatholMicrobiol 36, 1993, 383-8.
  19. [19]. Soloman S, Anuradha S, Rajasekaran S. Trend of HIV infection in patients with pulmonary tuberculosis in south India. Tuber Lung Dis 76(1), 1995, 17-9.
  20. [20]. Soloman S, Anuradha S, Ganapathy M, Jagadeshwari. Sentinel surveillance of HIV-1 infection in Tamil Nadu, India. Int J STD AIDs, 5, 1994, 445-6.
  21. [21]. TB &HIV co infection, statistics, diagnosis & treatment. Ref 7.‘International Classification of Diseases’ WHO, Geneva, 2010.