Evaluation Of Anti-Anxiety And Anticonvulsant Potential Of Ochna Vibecarpa Leaf Extracts

Abstract

Medicinal plants are an important source of bioactive compounds with potential therapeutic applications in neurological disorders. The present study aimed to evaluate the anti-anxiety and anticonvulsant activities of leaf extracts of Ochna vibecarpa, a plant belonging to the family Ochnaceae and traditionally used for various medicinal purposes. Preliminary phytochemical screening of the aqueous extract revealed the presence of carbohydrates, tannins, proteins, and resins. The anxiolytic activity was assessed using Elevated Plus Maze (EPM) and Open Field Test (OFT) models in Wistar rats, while anticonvulsant activity was evaluated using Maximal Electroshock (MES) and Pentylenetetrazole (PTZ)-induced seizure models. The animals were treated with two doses of Ochna vibecarpa extract (100 mg/kg and 200 mg/kg), and their effects were compared with standard drugs such as diazepam and phenytoin. The results demonstrated a significant increase in open arm entries and time spent in open arms in the EPM test, along with increased locomotor activity in the OFT, indicating notable anxiolytic effects. In anticonvulsant studies, the extract produced a dose-dependent reduction in seizure duration in MES models and significantly delayed seizure onset in PTZ-induced convulsions, with 100% protection observed at both dose levels. The higher dose (200 mg/kg) showed effects comparable to standard drugs.The findings suggest that Ochna vibecarpa leaf extract possesses significant anti-anxiety and anticonvulsant activities, which may be attributed to its phytochemical constituents and possible modulation of neurotransmitter systems. This study supports its traditional use and highlights its potential as a natural therapeutic agent for neurological disorders.