Main Article Content
Abstract
The study has been designed to get better understanding about the actions of aqueous, alcohol extract and crude powder of Wrightia tinctoria leaves on the behavioral health of wistar albino rat. Spontaneous motor activity of Wistar albino rats, Motor coordination in rats, Assessment of learning and memory in rats.
The animals were divided into 4 groups, each group with 6 animals. Following is the treatment allocation for the groups:
Group –I control group 1.0 ml-distilled water (vehicle) was administered
Group –II was administered aqueous extract (200 mg/kg ) in 1.0 ml of vehicle.
Group -III was administered leaf powder (500mg/kg ) in 1.0 ml of vehicle.
Group -IV was administered alcohol extract (200 mg/kg ) in 1.0 ml of vehicle.
The data obtained were assessed for their statistical significance by using the tukey’s test of one-way ANOVA.
There is no statistical significant difference (p<0.005) occurs between control and study groups in all the three parameters under study. No significant alteration has been noticed in the motor activity of the animals subjected to treatment with the test substances as indicated by the results of the photoactometer analysis. Similarly motor coordination has been found to be unaltered following treatment with the leaf powder or extracts under investigation. Treatment with leaf extract or powder did not alter learning and memory in rats as indicated by the results of the maze test.
Absence of any alteration in the behavioral parameters are indicative of lack of CNS influence by the plant.
Keywords
Article Details
References
- [1]. Toshihiro akihisa, ishtiaque ahmad, sukhprit singh, toshitake tamura and taro matsumoto. 14methylzymosterol and other sterols from Wrightia tinctoria seeds. Phytochemistry. 27(10), 1988, 3231- 3234.
- [2]. Reddy YSR, Sama Venkatesh, Ravichandran T, Murugan V, Suresh B. Antinociceptive activity of Wrightia tinctoria Bark. Fitoterapia 73, 2002, 421-423.
- [3]. Jafri MA. and Amin KMY. A neuropharmacological study of Lisanul Asaflr, (Seeds of Wrightia tinctoria) - a Unani herbal drug. Indian Journal of Pharmacology 14, 2001, 107-109
- [4]. Bhattacharyya D, mukherjee R, pandit S, das N, sur TK. Prevention of carbon tetrachloride induced hepatotoxicity in rats by himoliv a polyherbal formulation. Indian Journal of Pharmacology 35, 2003, 183-185.
- [5]. Vijayakumar R, Muthukumar C, Kumar T, Saravanamuthu R Characterization of Malassezia Furfur and its control by using plant extracts. Indian J Dermatology 51, 2006, 145-148
- [6]. Krishnamoorthy JR, Ranganathan S. Antipityrosporum ovale activity of a herbal drug combination of Wrightia tinctoria and hisbiscus rosasinensis. Indian J Dermatology 45, 2000, 125-6.
References
[1]. Toshihiro akihisa, ishtiaque ahmad, sukhprit singh, toshitake tamura and taro matsumoto. 14methylzymosterol and other sterols from Wrightia tinctoria seeds. Phytochemistry. 27(10), 1988, 3231- 3234.
[2]. Reddy YSR, Sama Venkatesh, Ravichandran T, Murugan V, Suresh B. Antinociceptive activity of Wrightia tinctoria Bark. Fitoterapia 73, 2002, 421-423.
[3]. Jafri MA. and Amin KMY. A neuropharmacological study of Lisanul Asaflr, (Seeds of Wrightia tinctoria) - a Unani herbal drug. Indian Journal of Pharmacology 14, 2001, 107-109
[4]. Bhattacharyya D, mukherjee R, pandit S, das N, sur TK. Prevention of carbon tetrachloride induced hepatotoxicity in rats by himoliv a polyherbal formulation. Indian Journal of Pharmacology 35, 2003, 183-185.
[5]. Vijayakumar R, Muthukumar C, Kumar T, Saravanamuthu R Characterization of Malassezia Furfur and its control by using plant extracts. Indian J Dermatology 51, 2006, 145-148
[6]. Krishnamoorthy JR, Ranganathan S. Antipityrosporum ovale activity of a herbal drug combination of Wrightia tinctoria and hisbiscus rosasinensis. Indian J Dermatology 45, 2000, 125-6.