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Apr 7, 2021
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Apr 7, 2021
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Abstract

Background


A Generic drug is a pharmaceutical product usually intended to be interchangeable with an innovator product that is manufactured without any license from the innovator company and marketed after the expiry date of the patent or other exclusive rights. The generic drug can be equivalent to branded formulations if they have the same pharmaceutical form, therapeutic indications and similar bioequivalence [20%]. There is an increased report of adverse events against the active drug ingredient of the generic drugs. Many of these factors lead to the increased confusion in the medical field on prescribing drugs. The antimicrobial resistance is a global problem, probably due to the indiscriminate and irrational use of antibiotics, prescriptions for incorrect medicines or incorrect determinations of dose, route and/or duration [16].  Antibiotics are type of antimicrobial drugs used in the treatment and prevention of bacterial infections. There is increased incidence of resistance against many antibiotics which contributes to the serious emerging and re emerging infections. In this study the antibacterial activities of different generic and branded amikacin were compared againstescherichia coli -In vitro.


Methods


In this experiment one generic amikacin (mikastar) and five branded amikacin were taken and coded. The urine samples of the patient with UTI were collected in the hospital under aseptic precautions and the E.colicoloniessensitive to amikacin were isolated by using antibiotic sensitivity test by means of Kirby Bauer disk diffusion method using amikacin disc and the E.coli sensitive to it were isolated based on the zone of inhibition to the amikacin.


 To know the antimicrobial activities of the drug, the minimum inhibitory concentration (MIC) of the antibiotics were calculated by using serial macro broth dilution method.


Results


Based on the above experiments done, the generic and the branded antibiotics were equally efficacious against the Escherichia coli.


Conclusions


All the samples of the antibiotics taken are pharmaceutical equivalents and the products can be used in antimicrobial therapy [16].

Keywords

Branded drug Generic drug Minimal inhibitory concentration Bioequivalence Amikacin E.coli Macrobrothdilution Antibiotic sensitivity test Disc diffusion method

Article Details

How to Cite
M.SaravanaKumar, Elakiya Elango, & Sageera Banoo. (2021). An analytic comparitive study about the antimicrobial activity of different generic and branded Amikacin on Escherichia coli - an In vitro study. International Journal of Research in Pharmacology & Pharmacotherapeutics, 8(2), 210-220. https://doi.org/10.61096/ijrpp.v8.iss2.2019.210-220
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