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Abstract
The nephroprotective effect of whole plant of ethanolic extract of Heliotropium indicum was confirmed by our study. In Rifampicin treated group urea, uric acid and creatinine levels are increased in serum and urine whereas decreased total protein levels. In the present study, the whole plant of ethanolic extract of Heliotropium indicum significantly reduced the toxicant elevated levels of above mentioned parameters and increased in the levels of protein. Hence at this point it is concluded that the extract of Heliotropium indicum offers nephroprotection. Based on improvement in serum and urine marker levels, histopathological studies, level of antioxidant enzymes and presence of phytoconstituents, it is concluded that the ethnolic extract of Heliotropium indicum possesses nephron protective activity and thus supports the traditional application of the same under the light of modern science.
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References
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- [2]. Chugh KS, Singhal PC. Acute renal failure in the tropic. In: Asian manual of nephrology. Seamic Tokyo, 1981, 180-7.
- [3]. Shelke TT, Kothari R. Nephroprotective activity of ethanolic extract of dried fruits of Pedalium murex Linn. J. Cell Tissue Res., 9, 2009, 1687-90.
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- [9]. Ohkawa H., Ohishi N., Yagi K., Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction, Anal Biochem., 95, 1979, 51-58.
- [10]. Rotruck JT, Pope AL, Ganther HL, Swanson AB. Selenium: biochemical role as a component of glutathione peroxidase. Science, 179, 1973, 588-590.
- [11]. Marklund A., Marklund G. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem, 47, 1974, 469-474.
References
[1]. Cooper K, Bennett WM. Nephrotoxicity of common drugs used in clinical practice. Arch Intern Med, 147, 1987, 1213-20.
[2]. Chugh KS, Singhal PC. Acute renal failure in the tropic. In: Asian manual of nephrology. Seamic Tokyo, 1981, 180-7.
[3]. Shelke TT, Kothari R. Nephroprotective activity of ethanolic extract of dried fruits of Pedalium murex Linn. J. Cell Tissue Res., 9, 2009, 1687-90.
[4]. Young DS. Effects of drugs on Clinical Lab. Tests, AACC Press. 4, 1995.
[5]. Thomas L. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesell Schaft, 1998, 208-14.
[6]. Tietz, N.W., Clinical guide to laboratory tests, 3rd Ed, (W.B. Saunders eds. Philadelphia USA), 1995, 624.
[7]. Christensen, S.E., Proteins. Clinical Chemistry: Concepts and Application, Anderson, S.C., Cockayne, S. (W.B. Saunders eds. Philadelphia USA), 188, 1983.
[8]. Tiez, N.W., Clinical guide to laboratory tests. 3rd Ed, (W.B. Saunders eds. Philadelphia USA), 518, 1995.
[9]. Ohkawa H., Ohishi N., Yagi K., Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction, Anal Biochem., 95, 1979, 51-58.
[10]. Rotruck JT, Pope AL, Ganther HL, Swanson AB. Selenium: biochemical role as a component of glutathione peroxidase. Science, 179, 1973, 588-590.
[11]. Marklund A., Marklund G. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem, 47, 1974, 469-474.