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Abstract
Osteoarthritis (OA) is a chronic, progressive joint disorder that affects millions of individuals worldwide and significantly impairs daily functioning and quality of life. Persistent pain, stiffness, and restricted mobility often limit independence, particularly among older adults. Although oral non-steroidal anti-inflammatory drugs (NSAIDs) remain widely prescribed, their long-term use is frequently associated with adverse systemic effects. Herbal transdermal films have recently emerged as a promising therapeutic approach that combines traditional medicinal knowledge with modern drug-delivery technology. These systems enable sustained and localized delivery of plant-derived bioactive compounds directly to affected joints, thereby reducing systemic exposure. This review critically examines current research on herbal transdermal films for osteoarthritis, including formulation strategies, pharmacological mechanisms, preclinical and clinical evidence, safety considerations, and future prospects. Available studies suggest encouraging therapeutic potential; however, well-designed clinical trials are required to establish their long-term efficacy and safety. With continued scientific validation, herbal transdermal films may become valuable components of patient-centered osteoarthritis management.