Main Article Content
Abstract
Lipoxygenases are oxidative enzymes involved in the metabolism of polyunsaturated fatty acids like linoleic acid and arachidonic acid that result in the formation of lipid hydroperoxides. In uncontrolled lipoxygenase enzyme activity leads to the generation of inflammatory mediators and also oxidative stress. In humans these enzymes have a major role in the biosynthesis of pro-inflammatory compounds that are involved in the development of chronic inflammatory conditions and also diseases such as cardiovascular diseases such as stroke and heart attack and neurodegenerative disorders. So inhibiting lipoxygenase activity has become a key approach for managing inflammatory disorders.
So based on this, an investigation was conducted to examine the in vitro inhibitory test potential of the test substance (Caesalpinia crista) using a spectrophotometric enzyme inhibition assay. And the test substance exhibited potent inhibition of the lipoxygenase enzyme when compared with the standard drug (Quercetin).