Main Article Content
Abstract
Background
Cardiovascular disease is the leading cause of death globally. India has become a country with more cardiac patients. India has become a country with more number of cardiovascular disease patients. Study of prescribing pattern can give trend in using the drugs in coronary artery disease in treating there comorbid conditions. The information of prescribing pattern can lead us toward the rational drug use helps to take measures to enhance prescribing habits. Multi morbidity is common in old age. Death’s related with cardiovascular events remain in constant in many countries due to latest therapeutic approaches for prevention and treatment in cardiovascular disease .This condition is widely associated with risk factors such as Hypertension ,Diabetes mellitus, alcohol consumption and sedentary lifestyle which plays an important role in cardiovascular diseases.
Objectives
The objectives of this study was to evaluate coronary artery disease prevalence and drug utilization in pattern in the department of the secondary care hospital in Hyderabad, India.
Study Design
A cross sectional study was carried out in general medicine department, Thumbay New Life Hospital Chaderghat using a well designed patient collected well defined form.
Results
In this study among 250 case of coronary artery disease analysed, which consist of male n=156 (62%) and females where n=94(38%). The incidence of CAD was more common in males than in females. In this study two different types of coronary artery disease were identified which includes angina pectoris patients and myocardial infarction patients (MI). Most of the patients with coronary artery disease where of the age group of 41-60 the most common comorbid conditions were hypertension 75(30%), hypertension and diabetes 72(29%) , hypertension and others (CKD ,hypothyroidism, dyslipidemia) 52(20%). The prescribing pattern of various cardiovascular drugs were found to be –antiplatelet drugs 250(89.6%), anti hyperlipidemic drugs 167 (66%), antibiotic drugs 99(21.6%), anti angina drugs 320(130%), antihypertensive drugs 207(64.8%), anticoagulants 138(66.4%) , diuretics 142(53.6%), bronchodilators 19(14.8%)
Out of 250 patients, 47(47.47%) patients had diabetes mellitus. Most of the patients were prescribed with human actrapid insulin and Human Mixtard Insulin during hospital stay. The doses of insulin were given based on the blood glucose levels. Very few patients were prescribed with oral hypoglycaemic agents. The total no: of drugs prescribed among 250 in-patients (prescriptions) with the diagnosis of coronary artery disease included in the study was 1235. The average number of drugs per prescription was determined and found to be 4.94% (Table 14). The number of drugs prescribed by generic name was only 431(34.8%). Aspirin 161, Atorvastatin 127, Amlodipine 8, Paracetamol 99, Pantoprazole 36 were the drugs prescribed by generic name.
Conclusion
Uncontrolled DM, hypertension, hyperlipidemia are risk factors for coronary artery disease. Anti-fibrinolytics followed by statins, anti-diabetics and anti hypertensives were most prescribed drugs. Combination drugs were prescribed patients were effective therapeutic. The present study will help health care professionals to modify the efficient and safe cardiovascular disease.
Keywords
Article Details
References
- [1]. Muhammad AtifEmail author, Muhammad Rehan Sarwar, Muhammad AzeemEmail author, Danial Umer, Abdul Rauf, Arslan Rasool, Muhammad Ahsan and Shane Scahill. Assessment of WHO/INRUD core drug use indicators in two tertiary care hospitals of Bahawalpur, Punjab, Pakistan. Journal of Pharmaceutical Policy and Practice 9, 2016.
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- [6]. Ram Rohit V, Chauhan Rajendrasinh B, Trivedi Atul V. Type A Personality & Coronary Artery Disease: A Case Control Study. Journal of Research in Medical and Dental Science. 4(1), 2016, 50-3
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- [8]. Ayse Akbas, Fadime Kilinc. Analysis of the patients with lichenoid drug reactions: a retrospective study. Medical Science and Discovery. 5(3), 2018, 153-60
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- [10]. Barbara H. Braffett, Samuel Dagogo-Jack, Ionut Bebu, William I. Sivitz, Mary Larkin, Orville Kolterman and John M. Lachin. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 42(4), 2019, 657-664.
References
[1]. Muhammad AtifEmail author, Muhammad Rehan Sarwar, Muhammad AzeemEmail author, Danial Umer, Abdul Rauf, Arslan Rasool, Muhammad Ahsan and Shane Scahill. Assessment of WHO/INRUD core drug use indicators in two tertiary care hospitals of Bahawalpur, Punjab, Pakistan. Journal of Pharmaceutical Policy and Practice 9, 2016.
[2]. Banerjee S, Kumar V, Ramachandran P, Kamath A. Does The Pharmacological Management Of Unstable Angina Vary With Age And Gender – A Descriptive Study. Journal of Clinical and Diagnostic Research. 4(6), 3150 – 3157
[3]. Nimbagiri Swamy Thiruthopu, Uday Venkat Mateti, Raju Bairi, Divya Sivva, and Srinivas Martha. Drug utilization pattern in South Indian pediatric population: A prospective study. Perspectives in Clinical Research (PICR). 5(4), 2014, 178–183.
[4]. Massimo Bolognesi, Diletta Bolognesi. Misdiagnosis of Angina Pectoris Due to Severe Coronary Artery Disease: An Anecdotal Case. ResearchGate. 3, 2014, 331-335
[5]. E E van der Wall. Mortality decrease from cardiovascular disease in Europe: 50 % in 30 years. 21(10), 2013.
[6]. Ram Rohit V, Chauhan Rajendrasinh B, Trivedi Atul V. Type A Personality & Coronary Artery Disease: A Case Control Study. Journal of Research in Medical and Dental Science. 4(1), 2016, 50-3
[7]. Shruthi Dawalji, Venkateshwarlu K, Sridhar Thota, Praveen Kumar Venisetty, Raj Kumar Venisetty. Prescribing Pattern in Coronary Artery Disease: A Prospective Study. International Journal of Pharma Research & Review, International Journal of Pharma Research & Review. 3(3), 2014, 24-33
[8]. Ayse Akbas, Fadime Kilinc. Analysis of the patients with lichenoid drug reactions: a retrospective study. Medical Science and Discovery. 5(3), 2018, 153-60
[9]. Philip J. Barter. The Causes and Consequences of Low Levels of High Density Lipoproteins in Patients with Diabetes. National Center for Biotechnology Information 35(2), 2011, 101–106.
[10]. Barbara H. Braffett, Samuel Dagogo-Jack, Ionut Bebu, William I. Sivitz, Mary Larkin, Orville Kolterman and John M. Lachin. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 42(4), 2019, 657-664.