Main Article Content
Abstract
Background
Physalis Minima is a commonly known as Ground cherry or Sun berry. It belongs to the family solanaecia. It is a common species found in India & posses Anti-inflammatory, analgesic antipyretic, Antifertility Antimicrobial activity, New leishmanicidal ,Antiulcer and anti-oxidant activity etc..
Aims & Objectives
Evaluation of analgesic activity of Physalis Minima flowers & leaves.
Materials and methods
48 adult albino mice (50 g body weight) were used in this study. Which were divided in to 8 groups containing 6 mice in each group. Aqueous eatract of physalis minima flowers and leaves are used for the evaluation of analgesic activity by tail flick and hot plate method by oral administration at doses of 100,200, 400 mg/kg body weight in healthy albino mice.
Results
The Aqueous extract of Physalis Minima leaves and flowers at doses of 100,200, 400 mg/kg body weight showed significant analgesic activity when compared with the control and standard drug. Results are expressed as mean ± standard error of mean (SEM). Data was analyzed by one way ANOVA (analysis of variance). P value less than 0.01 considered as significant.
Conclusion
Aqueous Extract of Physalis Minima flowers & leaves at all different doses posses analgesic effect
Keywords
Article Details
References
- [1]. Satyavati GV, Guptha AK, Tendon N. Medicinal plants of India. New Delhi: Indian Council of Medical Reasearch, 1987 .pp. 289 – 99.
- [2]. R. Polat, U. Cakilcioglu, and F. Satil, “Traditional uses of medicinal plants in Solhan ( Bingol – Turkey),” Journal of Ethnopharmacology, vol. 148, no. 3, pp.951-963,2013.
- [3]. A.M. Vittalrao, T. Shanbhag, K. M. Kumari, K. I. Bairy, and S. Shenoy, “Evaluation of anti-inflammatory and analgesic activities of alcoholic extract of Kaempferia galangal in rats,” Indian Journal of Physiology and Pharmacology, vol. 55, no.1,pp.13- 24, 2011.
- [4]. B. B. Kakoti, P. Pradhan, S. Borah, K. M. Kumari, K. Mahato, and M. Kumar, “Analgesic and anti- inflammatory activities of the methanolic stem bark extract of Nyctanthes arbor- trists Linn.,” Bio Med Reserch International, vol. 2013, Article ID 826295, 6 pages, 2013.
- [5]. Daya l Chothani, H U Vagasiga pharmacological overview of physalis minima in Indian journal of natural products & researches 3(4)) Dec 2012 pp142
- [6]. Mahendra Sahai and Isaac Kirson Withaphysalin D, A New Withaphysalin from Physalis minima Linn. Var. Indica / / J. Nat. Prod., 1984, 47 (3), pp 527–529 / DOI: 10.1021/np50033a022 5)
- [7]. S Sudhakaran, B Ramanathan Antifertility Effects Of The Petroleum Ether Extract Of Physalis Minima On Female Albino Rats Pharmaceutical Biology / 1999, Vol. 37, No. 4, Pages 269-272
- [8]. L Ma, XW Gan, QP He, HY Bai, M Arfan Cytotoxic Withaphysalins From Physalis Minima/ Lei Ma Et Al / Helvetica Chimica Acta • Volume 90 Issue 7, Pages 1406 - 1419 / 10.1002/Hlca.200790143 Doi
- [9]. Ooi Kheng Leong, Tengku Sifzizul Tengku Muhammad, and Shaida Fariza Sulaiman et al Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis / Ooi Kheng Leong et al / Oxford Journals Medicine Evidence-based Compl. and Alt. MedicineeCAM Advance Access10.1093/ ecam/nep057
- [10]. Ooi K L, Tengku Muhammad et al / Apoptotic effects of Physalis minima L. chloriform extract in human breast carcinoma T-47D cells mediated by c-myc-p 53-& caspase - 3-dependent pathways / Ooi K L, Tengku Muhammad et al / Integrated Cancer Therapy. 2010 Mar;9(1):73-83. Epub 2010 Feb 11
- [11]. T. Joshi Anand*, R. Ratna Manjula, SK. Liakhat Ali, M. Hindu Sai and V. Padmaja anti-ulcer activity of physalis minima plant extract in albino rats,International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.5, No.2, pp 337-340, April-June 2013
- [12]. Nayeemulla Shariff 1 , M. S. Sudarshana 1 , S. Umesha 2 * and P. Hariprasad Antimicrobial Activity Of Rauvolfia Tetraphylla And Physalis Minima Leaf And Callus Extracts African Journal Of Biotechnology Vol. 5 (10), Pp. 946-950, 16 May 2006 080/14756360802321120
- [13]. Murad Ali Khan, Haroon Khan, Sarwar Khan, Tahira Mahmood, Pir Mohammad Khan & Abdul Jabar Anti-inflammatory, Analgesic And Antipyretic Activities Of Physalis Minima Linn / Murad Ali Khan Et Al / Journal Of Enzyme Inhibition And Medicinal Chemistry, Volume 24, Issue 3 June 2009 , Pages 632 - 637 / DOI:
- [14]. Sathis Kumar D.* , Raju S.N., Harani A., Banji David, Rao K.N.V., Banji Otilia Nalanda College of Pharmacy, Nalgonda -508 001, Andhra Pradesh, India. Alpha- Glucosidase inhibitory & Hypoglycemic Activities of Physalis Minima Extract / Sathis Kumar, Raju S N et al / Pharmacognosy Journal, Dec 2009, Vol 1, Issue 4, Pp 273-278.
References
[1]. Satyavati GV, Guptha AK, Tendon N. Medicinal plants of India. New Delhi: Indian Council of Medical Reasearch, 1987 .pp. 289 – 99.
[2]. R. Polat, U. Cakilcioglu, and F. Satil, “Traditional uses of medicinal plants in Solhan ( Bingol – Turkey),” Journal of Ethnopharmacology, vol. 148, no. 3, pp.951-963,2013.
[3]. A.M. Vittalrao, T. Shanbhag, K. M. Kumari, K. I. Bairy, and S. Shenoy, “Evaluation of anti-inflammatory and analgesic activities of alcoholic extract of Kaempferia galangal in rats,” Indian Journal of Physiology and Pharmacology, vol. 55, no.1,pp.13- 24, 2011.
[4]. B. B. Kakoti, P. Pradhan, S. Borah, K. M. Kumari, K. Mahato, and M. Kumar, “Analgesic and anti- inflammatory activities of the methanolic stem bark extract of Nyctanthes arbor- trists Linn.,” Bio Med Reserch International, vol. 2013, Article ID 826295, 6 pages, 2013.
[5]. Daya l Chothani, H U Vagasiga pharmacological overview of physalis minima in Indian journal of natural products & researches 3(4)) Dec 2012 pp142
[6]. Mahendra Sahai and Isaac Kirson Withaphysalin D, A New Withaphysalin from Physalis minima Linn. Var. Indica / / J. Nat. Prod., 1984, 47 (3), pp 527–529 / DOI: 10.1021/np50033a022 5)
[7]. S Sudhakaran, B Ramanathan Antifertility Effects Of The Petroleum Ether Extract Of Physalis Minima On Female Albino Rats Pharmaceutical Biology / 1999, Vol. 37, No. 4, Pages 269-272
[8]. L Ma, XW Gan, QP He, HY Bai, M Arfan Cytotoxic Withaphysalins From Physalis Minima/ Lei Ma Et Al / Helvetica Chimica Acta • Volume 90 Issue 7, Pages 1406 - 1419 / 10.1002/Hlca.200790143 Doi
[9]. Ooi Kheng Leong, Tengku Sifzizul Tengku Muhammad, and Shaida Fariza Sulaiman et al Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis / Ooi Kheng Leong et al / Oxford Journals Medicine Evidence-based Compl. and Alt. MedicineeCAM Advance Access10.1093/ ecam/nep057
[10]. Ooi K L, Tengku Muhammad et al / Apoptotic effects of Physalis minima L. chloriform extract in human breast carcinoma T-47D cells mediated by c-myc-p 53-& caspase - 3-dependent pathways / Ooi K L, Tengku Muhammad et al / Integrated Cancer Therapy. 2010 Mar;9(1):73-83. Epub 2010 Feb 11
[11]. T. Joshi Anand*, R. Ratna Manjula, SK. Liakhat Ali, M. Hindu Sai and V. Padmaja anti-ulcer activity of physalis minima plant extract in albino rats,International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.5, No.2, pp 337-340, April-June 2013
[12]. Nayeemulla Shariff 1 , M. S. Sudarshana 1 , S. Umesha 2 * and P. Hariprasad Antimicrobial Activity Of Rauvolfia Tetraphylla And Physalis Minima Leaf And Callus Extracts African Journal Of Biotechnology Vol. 5 (10), Pp. 946-950, 16 May 2006 080/14756360802321120
[13]. Murad Ali Khan, Haroon Khan, Sarwar Khan, Tahira Mahmood, Pir Mohammad Khan & Abdul Jabar Anti-inflammatory, Analgesic And Antipyretic Activities Of Physalis Minima Linn / Murad Ali Khan Et Al / Journal Of Enzyme Inhibition And Medicinal Chemistry, Volume 24, Issue 3 June 2009 , Pages 632 - 637 / DOI:
[14]. Sathis Kumar D.* , Raju S.N., Harani A., Banji David, Rao K.N.V., Banji Otilia Nalanda College of Pharmacy, Nalgonda -508 001, Andhra Pradesh, India. Alpha- Glucosidase inhibitory & Hypoglycemic Activities of Physalis Minima Extract / Sathis Kumar, Raju S N et al / Pharmacognosy Journal, Dec 2009, Vol 1, Issue 4, Pp 273-278.