Main Article Content
Abstract
Background: Trigeminal neuralgia (TN) causes severe facial pain, often triggered by touch or chewing, due to nerve compression. Traditional treatments, like anticonvulsants and surgery, may have side effects and limited effectiveness. Low-intensity laser therapy (LILT) is being explored as an alternative, showing promise in pain reduction and nerve healing. This review evaluates LILT's efficacy in managing TN.
Methodology: A comprehensive literature study was done using the specified search criteria. To carry out a literature review, the search phrases "efficacy of low-intensity laser therapy in trigeminal neuralgia" were employed between the years 2014 and 2024. We have discovered 10 publications with complete text and methodologies for additional examination from diverse academic journals.
Results: We discovered 10 publications that included a low intensity laser therapy for all individuals. All articles designed for low intensity laser therapy patients showed benefits in all intervention groups.
Conclusion: The review included 10 studies that utilized distinct low-intensity laser therapy protocols across various patient populations. All included articles reported positive outcomes, indicating the effectiveness of low-intensity laser therapy across different intervention groups
Keywords
Trigeminal neuralgia (TN)
facial pain
Low-intensity laser therapy (LILT)
Article Details
How to Cite
Efficacy Of Low-Intensity Laser Therapy on Pain In Trigeminal Neuralgia – A Literature Review. (2025). International Journal of Research in Pharmacology & Pharmacotherapeutics, 14(2), 266-273. https://doi.org/10.61096/ijrpp.v14.iss2.2025.266-273
How to Cite
Efficacy Of Low-Intensity Laser Therapy on Pain In Trigeminal Neuralgia – A Literature Review. (2025). International Journal of Research in Pharmacology & Pharmacotherapeutics, 14(2), 266-273. https://doi.org/10.61096/ijrpp.v14.iss2.2025.266-273
References
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1. Burchiel KJ. Trigeminal neuralgia: Pathophysiology, diagnosis, and treatment. J Pain. 2004;5(3):4-14.
2. Merskey H, Bogduk N. Classification of Chronic Pain. IASP Press; 1994
3. Cohen G, Burchiel KJ. Trigeminal neuralgia and the role of medical therapy. Neurosurgery. 2007;60(1):14-22.
4. Jannetta PJ. The cause of trigeminal neuralgia: Vascular compression of the trigeminal nerve. N Engl J Med. 1996;334(1):2-5.
5. Gilden DH. Trigeminal neuralgia and multiple sclerosis. Neurology. 2005;65(2):318-319.
6. Karagözoğlu İ, Demirkol N, Parlar Öz Ö, Keçeci G, Çetin B, Özcan M. Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial. Journal of Clinical Medicine. 2024 Nov 15;13(22):6890.
7. Maryam Jalili Sadrabad, Alireza Pedram, Elham Saberian, Emami R. Clinical efficacy of LLLT in treatment of trigeminal neuralgia – Case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023 Nov 1;35(6):568–71.
8. Laís Tatiane Ferreira, Viviane Brocca Souza, Simone Aparecida Ferreira, Gabriely Simão, Antonio Eduardo Aquino, Marcelo Saito Nogueira, et al. Application of low-level laser therapy in trigeminal neuralgia: a clinical case. 2023 Mar 14;
9. Ren H, Liu J, Liu Y, Yu C, Bao G, Kang H. Comparative effectiveness of low‐ level laser therapy with different wavelengths and transcutaneous electric nerve stimulation in the treatment of pain caused by temporomandibular disorders: A systematic review and network meta‐analysis. Journal of Oral Rehabilitation. 2021 Aug 21;49(2):138–49.
10. Hansen HJ, Thorøe U. Low power laser biostimulation of chronic oro-facial pain. A double-blind placebo controlled cross-over study in 40 patients. Pain. 1990 Nov;43(2):169–79.
11. Antonio, Marques MC, Luiz, Fabiola, Carla S, Cristina M. The use of laser phototherapy in the management of trigeminal neuralgia pain: two decades of clinical experience. Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE. 2017 Feb 17;10048:1004808–8.
12. Intsar S. Waked, Low Level Laser Therapy for the treatment of Trigeminal Neuralgia after Oral surgeries: Two Different Applications 2015 4
13. Vernon L, Hasbun R. Low-level Laser Therapy for Trigeminal Neuralgia. Pract Pain Manag. 2008;8(6).
14. Farnaz Falaki, Nejat A, Zohreh Dalirsani. The Effect of Low-level Laser Therapy on Trigeminal Neuralgia: A Review of Literature. 2014 Jan 1.
15. Kim HK, Jung JH, Kim CH, Kwon JY, Baik SW. The Effect of Lower Level Laser Therapy on Trigeminal Neuralgia. The Korean journal of pain. 2003 Jan 1;16(1):37–41.
16. Sutherland, J. E., Kellett, C. A., & Taylor, R. H. (2018). The role of low-level laser therapy in the treatment of trigeminal neuralgia: A review of the literature. Journal of Pain Research, 11, 929-938.
17. Omar, S. H., Ibrahim, S. A., & Kassem, A. (2015). Low-level laser therapy for trigeminal neuralgia: A randomized controlled trial. Journal of Pain Research, 8, 517-523.
18. Gupta, A., Sood, A., & Sharma, S. (2012). The role of low-level laser therapy in trigeminal neuralgia. International Journal of Dentistry, 2012, 1-5.
19. Huang, Y. Y., Chen, A. C., & Carreiro, J. (2014). Mechanisms of photobiomodulation in the treatment of chronic pain. Laser in Medical Science, 29(1), 31-37.
20. Al-Waili, N., Saloom, K., & Al-Waili, W. (2011). The effects of low-level laser therapy on trigeminal neuralgia: A systematic review. Journal of Photochemistry and Photobiology B: Biology, 102(3), 139-145.
21. Bajaj, S., Jadhav, S. B., & Garg, S. (2017). Low-level laser therapy in trigeminal neuralgia: A case study. Indian Journal of Palliative Care, 23(2), 229-231.
References
1. Burchiel KJ. Trigeminal neuralgia: Pathophysiology, diagnosis, and treatment. J Pain. 2004;5(3):4-14.
2. Merskey H, Bogduk N. Classification of Chronic Pain. IASP Press; 1994
3. Cohen G, Burchiel KJ. Trigeminal neuralgia and the role of medical therapy. Neurosurgery. 2007;60(1):14-22.
4. Jannetta PJ. The cause of trigeminal neuralgia: Vascular compression of the trigeminal nerve. N Engl J Med. 1996;334(1):2-5.
5. Gilden DH. Trigeminal neuralgia and multiple sclerosis. Neurology. 2005;65(2):318-319.
6. Karagözoğlu İ, Demirkol N, Parlar Öz Ö, Keçeci G, Çetin B, Özcan M. Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial. Journal of Clinical Medicine. 2024 Nov 15;13(22):6890.
7. Maryam Jalili Sadrabad, Alireza Pedram, Elham Saberian, Emami R. Clinical efficacy of LLLT in treatment of trigeminal neuralgia – Case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023 Nov 1;35(6):568–71.
8. Laís Tatiane Ferreira, Viviane Brocca Souza, Simone Aparecida Ferreira, Gabriely Simão, Antonio Eduardo Aquino, Marcelo Saito Nogueira, et al. Application of low-level laser therapy in trigeminal neuralgia: a clinical case. 2023 Mar 14;
9. Ren H, Liu J, Liu Y, Yu C, Bao G, Kang H. Comparative effectiveness of low‐ level laser therapy with different wavelengths and transcutaneous electric nerve stimulation in the treatment of pain caused by temporomandibular disorders: A systematic review and network meta‐analysis. Journal of Oral Rehabilitation. 2021 Aug 21;49(2):138–49.
10. Hansen HJ, Thorøe U. Low power laser biostimulation of chronic oro-facial pain. A double-blind placebo controlled cross-over study in 40 patients. Pain. 1990 Nov;43(2):169–79.
11. Antonio, Marques MC, Luiz, Fabiola, Carla S, Cristina M. The use of laser phototherapy in the management of trigeminal neuralgia pain: two decades of clinical experience. Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE. 2017 Feb 17;10048:1004808–8.
12. Intsar S. Waked, Low Level Laser Therapy for the treatment of Trigeminal Neuralgia after Oral surgeries: Two Different Applications 2015 4
13. Vernon L, Hasbun R. Low-level Laser Therapy for Trigeminal Neuralgia. Pract Pain Manag. 2008;8(6).
14. Farnaz Falaki, Nejat A, Zohreh Dalirsani. The Effect of Low-level Laser Therapy on Trigeminal Neuralgia: A Review of Literature. 2014 Jan 1.
15. Kim HK, Jung JH, Kim CH, Kwon JY, Baik SW. The Effect of Lower Level Laser Therapy on Trigeminal Neuralgia. The Korean journal of pain. 2003 Jan 1;16(1):37–41.
16. Sutherland, J. E., Kellett, C. A., & Taylor, R. H. (2018). The role of low-level laser therapy in the treatment of trigeminal neuralgia: A review of the literature. Journal of Pain Research, 11, 929-938.
17. Omar, S. H., Ibrahim, S. A., & Kassem, A. (2015). Low-level laser therapy for trigeminal neuralgia: A randomized controlled trial. Journal of Pain Research, 8, 517-523.
18. Gupta, A., Sood, A., & Sharma, S. (2012). The role of low-level laser therapy in trigeminal neuralgia. International Journal of Dentistry, 2012, 1-5.
19. Huang, Y. Y., Chen, A. C., & Carreiro, J. (2014). Mechanisms of photobiomodulation in the treatment of chronic pain. Laser in Medical Science, 29(1), 31-37.
20. Al-Waili, N., Saloom, K., & Al-Waili, W. (2011). The effects of low-level laser therapy on trigeminal neuralgia: A systematic review. Journal of Photochemistry and Photobiology B: Biology, 102(3), 139-145.
21. Bajaj, S., Jadhav, S. B., & Garg, S. (2017). Low-level laser therapy in trigeminal neuralgia: A case study. Indian Journal of Palliative Care, 23(2), 229-231.
2. Merskey H, Bogduk N. Classification of Chronic Pain. IASP Press; 1994
3. Cohen G, Burchiel KJ. Trigeminal neuralgia and the role of medical therapy. Neurosurgery. 2007;60(1):14-22.
4. Jannetta PJ. The cause of trigeminal neuralgia: Vascular compression of the trigeminal nerve. N Engl J Med. 1996;334(1):2-5.
5. Gilden DH. Trigeminal neuralgia and multiple sclerosis. Neurology. 2005;65(2):318-319.
6. Karagözoğlu İ, Demirkol N, Parlar Öz Ö, Keçeci G, Çetin B, Özcan M. Clinical Efficacy of Two Different Low-Level Laser Therapies for the Treatment of Trigeminal Neuralgia: A Randomized, Placebo-Controlled Trial. Journal of Clinical Medicine. 2024 Nov 15;13(22):6890.
7. Maryam Jalili Sadrabad, Alireza Pedram, Elham Saberian, Emami R. Clinical efficacy of LLLT in treatment of trigeminal neuralgia – Case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023 Nov 1;35(6):568–71.
8. Laís Tatiane Ferreira, Viviane Brocca Souza, Simone Aparecida Ferreira, Gabriely Simão, Antonio Eduardo Aquino, Marcelo Saito Nogueira, et al. Application of low-level laser therapy in trigeminal neuralgia: a clinical case. 2023 Mar 14;
9. Ren H, Liu J, Liu Y, Yu C, Bao G, Kang H. Comparative effectiveness of low‐ level laser therapy with different wavelengths and transcutaneous electric nerve stimulation in the treatment of pain caused by temporomandibular disorders: A systematic review and network meta‐analysis. Journal of Oral Rehabilitation. 2021 Aug 21;49(2):138–49.
10. Hansen HJ, Thorøe U. Low power laser biostimulation of chronic oro-facial pain. A double-blind placebo controlled cross-over study in 40 patients. Pain. 1990 Nov;43(2):169–79.
11. Antonio, Marques MC, Luiz, Fabiola, Carla S, Cristina M. The use of laser phototherapy in the management of trigeminal neuralgia pain: two decades of clinical experience. Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE. 2017 Feb 17;10048:1004808–8.
12. Intsar S. Waked, Low Level Laser Therapy for the treatment of Trigeminal Neuralgia after Oral surgeries: Two Different Applications 2015 4
13. Vernon L, Hasbun R. Low-level Laser Therapy for Trigeminal Neuralgia. Pract Pain Manag. 2008;8(6).
14. Farnaz Falaki, Nejat A, Zohreh Dalirsani. The Effect of Low-level Laser Therapy on Trigeminal Neuralgia: A Review of Literature. 2014 Jan 1.
15. Kim HK, Jung JH, Kim CH, Kwon JY, Baik SW. The Effect of Lower Level Laser Therapy on Trigeminal Neuralgia. The Korean journal of pain. 2003 Jan 1;16(1):37–41.
16. Sutherland, J. E., Kellett, C. A., & Taylor, R. H. (2018). The role of low-level laser therapy in the treatment of trigeminal neuralgia: A review of the literature. Journal of Pain Research, 11, 929-938.
17. Omar, S. H., Ibrahim, S. A., & Kassem, A. (2015). Low-level laser therapy for trigeminal neuralgia: A randomized controlled trial. Journal of Pain Research, 8, 517-523.
18. Gupta, A., Sood, A., & Sharma, S. (2012). The role of low-level laser therapy in trigeminal neuralgia. International Journal of Dentistry, 2012, 1-5.
19. Huang, Y. Y., Chen, A. C., & Carreiro, J. (2014). Mechanisms of photobiomodulation in the treatment of chronic pain. Laser in Medical Science, 29(1), 31-37.
20. Al-Waili, N., Saloom, K., & Al-Waili, W. (2011). The effects of low-level laser therapy on trigeminal neuralgia: A systematic review. Journal of Photochemistry and Photobiology B: Biology, 102(3), 139-145.
21. Bajaj, S., Jadhav, S. B., & Garg, S. (2017). Low-level laser therapy in trigeminal neuralgia: A case study. Indian Journal of Palliative Care, 23(2), 229-231.