Pharmacological Evaluation Of Anti-Atheroslerotic Activity Of Tinospora Cordifolia In Animal Model

Abstract

Objective: To investigate the antiatherosclerotic activity of ethanol extract of Tinosporacordifolia in male Wistarrats.

Material & method: In this model of atherosclerosis, 30 adult male Wistar rats were evenly divided into 5groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4and5 were the treatments groups which were simultaneously treated with standard, 200and400mg/kg extract respectively along with High Fat Diet. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia.

Results: HFD caused atherosclerosis as evidenced by marked elevation in Cholesterol, Triglycerides, LDL, VLDL and decrease in HDL levels. Co-administration of extract with HFD decreased rise Cholesterol, Triglycerides, LDL, VLDL and incr

ease in HDL levels.

Conclusion: It was observed that the ethanol extract of Tinosporacordifolia conferred Anti- atherosclerotic activity by biochemical observation against HFD induced atherosclerosis in rats. In the near future could constitute lead to discovery of an ovel drug for treatment of drug induced atherosclerosis