Main Article Content
Abstract
This study investigates the pharmacognostic, antioxidant, and anti-diabetic properties of Abutilon crispum leaves, a medicinal plant traditionally used for treating various ailments. Abutilon crispum is examined for its potential role in diabetes management, using ethanolic extracts tested on streptozotocin (STZ)-induced diabetic rats. The study outlines both antioxidant and anti-diabetic evaluations. Antioxidant potential was assessed using hydroxyl, DPPH, and nitric oxide radical scavenging assays, showing a concentration-dependent increase in scavenging activity. For anti-diabetic evaluation, Wistar rats received oral doses of Abutilon crispum extract (200 mg/kg and 400 mg/kg), with blood glucose levels measured over 28 days. The 400 mg/kg dose demonstrated significant glucose-lowering effects, comparable to the standard anti-diabetic drug Glibenclamide. Biochemical analyses also revealed that Abutilon crispum extract improves liver function by reducing SGOT, SGPT, and alkaline phosphatase levels, and decreases oxidative stress by lowering lipid peroxidation and enhancing catalase and glutathione peroxidase activities. These findings underscore Abutilon crispum as a potential natural therapeutic agent for diabetes management and oxidative stress mitigation. Future research could further elucidate the mechanisms and isolate active compounds responsible for these effects.
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References
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References
1. Ansari, Essentional of Pharmacognosy, second edition, Birla publication, 575- 596. https://www.birlapublications.com/books-essential-of-pharmacognosy-18.php
2. Patwardhan B, Vaidya AD, Chorghade M. Ayurveda and natural products drug discovery. Current science. 2004 Mar 25:789-99.
3. Balick M.J, Cox, P.A.R., The science of ethanobotany, Scientific American Library, New .York USA 219. 1996.
4. Krishnaraju AV, Rao TV, Sundararaju D, Vanisree M, Tsay HS, Subbaraju GV. Assessment of bioactivity of Indian medicinal plants using brine shrimp (Artemia salina) lethality assay. International Journal of Applied Science and Engineering. 2005 Oct;3(2):125-34.
5. Laloo RC, Kharlukhi L, Jeeva S, Mishra BP. Status of medicinal plants in the disturbed and the undisturbed sacred forests of Meghalaya, northeast India: population structure and regeneration efficacy of some important species. Current science. 2006 Jan 25:225-32.
6. Gautam AK. The wealth of India: an encyclopedia of India's raw material resources. Pakistan Journal of Biological Sciences. 2001;15(5):449-507.
7. Barceló A, Rajpathak S. Incidence and prevalence of diabetes mellitus in the Americas. Revista Panamericana de Salud Pública. 2001 Nov;10(5):300-8.
8. Pari L, Saravanan R. Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats. Diabetes, Obesity and Metabolism. 2004 Jul;6(4):286-92.
9. Ashok K. Tiwari and J. MadhusudanaRao, Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects,Current Science,83(1),2002,30-38.
10. National Center for Chronic Disease Prevention and Health Promotion (U.S.), Division of Diabetes Translation., National diabetic facts. 2011.
11. Robert Ross, Damon Dagnone, Peter J.H. Jones, Heidi Smith, Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men, American College of Physicians–American Society of Internal Medicine. 2000,133(2);92-103.
12. Prema Chandra Sekhar, Some Ethno medicinal Plants used for the Treatment of Piles by the Kondadora Tribe of Northern Andhra Pradesh, A.P., India. International Journal of Ayurvedic and Herbal Medicine. 2012; 2(5) 803-809. https://interscience.org.uk/v2-i5/10%20ijahm.pdf
13. Kuchi Manjeera, Raja Sundararajan. In vitroantioxidant & antidiabetic activity of Abutilon crispum & Ficusdalhousiae, Eur. Chem. Bull. 2023,12(4), 2146-2159.
14. Ram Mohan M, Srinivas Reddy K , Ganapaty S , Hepatoprotective activity of the leaves of Abutilon crispum (linn) medicus World journal of pharmacy and pharmaceutical sciences, 2014; 3(11): 774-79.
15. Mohan R, Ganapaty S. Anti-Inflammatory and Toxicity Studies of the Leaves of Abutilon crispum. International Journal for Pharmaceutical Research Scholars. 2015;4:108-11.