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Paliperidone is a SR (5-HT2) receptor antagonist and D2DR inhibitor was BCS class II drug with low water solubility and the absolute oral bioavailability of Paliperidone following Paliperidone administration is 28%. So, it is essential to improve the solubility to enhance its bioavailability. Nanosuspension technique is a modern and a more innovative approach used widely to increase the solubility of the drug moieties. Nanosuspension of Paliperidone by solvent evaporation method using various polymers such as SLS, Pluronic F127, PVP-K90, PVA, and methanol. IR spectroscopic studies indicated that there are no drug-excepient interactions. All the prepared formulations were found to be having drug content within acceptable limits in the range of 79.26 to 97.52 % and Entrapment efficiency was found to be in the range of 82.16%-96.20% respectively. From the in vitro dissolution studies by comparing to other all the formulations F9 is the best formulation which showed 99.86% of drug released respectively within 60 min and follows Zero order release kinetics.


Paliperidone pluronic F127 PVP-K90 PVA Scanning Electron Microscopy(SEM) UV Spectroscopy

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How to Cite
Manjula Challa, S. Reshma, M. Pradeep kumar, & S. Lakshmi Sarada. (2024). A study on invitro Charectarisation of Paliperidone Nanosuspensions. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(2), 151-158. Retrieved from


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