Main Article Content
Abstract
AIM: This study aimed to evaluate the Anti-arthritic activity of the alcoholic extract of Phyllanthus acidus(L.) fruits in albino rats using suitable animal models.
METHODS: the Phyllanthus acidus(L.) plant was collected and authenticated. The fruits were dried for ten days subjected to get coarse powder. The course powder subjected to soxhlet apparatus by using various solvents. The phytochemical analysis was conducted using various tests. The arthritic activity was induced by using Freund’s adjuvant injection. The paw volume was assessed using plethysmometer.
RESULTS: the alcoholic extract of Phyllanthus acidus(L.) showed anti-arthritic activity in rats. The arthritic activity induced by Freund’s adjuvant injection was reduced in the treatment group, as observed in the plethysmometer.
CONCLUSION: the findings of the study suggest that the alcoholic extract of Phyllanthus acidus(L.) fruits possesses anti-arthritic activity, but in less and could be a therapeutic agent for the treatment of arthritis disease. Further studies required to explore the mechanism of action and safety of this extract.
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References
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- 2. Attjritis Foundation. https://www.arthritis.org/health-wellness/healthy-living/managing- pain/understanding-pain/sources-of-arthritis-pain.
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- 14. Gopika Gopinath, Sujesh M, Dr. Babu. T.D, Evaluation of Cytotoxic and Anti-Tumor Activity of Phyllanthus Acidus (L.) Skeels Leaf Extracts, 2015; 2(2):19-26.
- 15. Foyzun T, Aktar K, Uddin MA. Evaluation of antioxidant, cytotoxic and antimicrobial activity of Phyllanthus acidus. Int J Pharmacogn Phytochem Res. 2016;8(11):1751-8.
- 16. Moniruzzaman M, Asaduzzaman M, Hossain MS, Sarker J, Rahman SA, Rashid M, Rahman MM. In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus. BMC complementary and alternative medicine. 2015 Dec;15:1-0. https://link.springer.com/article/10.1186/s12906-015-0930-y
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References
1. NIH, Rheumatoid Arthritis. https://www.niams.nih.gov/health-topics/rheumatoid-arthritis.
2. Attjritis Foundation. https://www.arthritis.org/health-wellness/healthy-living/managing- pain/understanding-pain/sources-of-arthritis-pain.
3. Clevel and clinic. Arthritis. https://my.clevelandclinic.org/health/diseases/12061-arthritis.
4. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 2007 Feb;147(2):227-35. doi: 10.1111/j.1365-2249.2006.03261.x. PMID: 17223962; PMCID: PMC1810472.
5. Cotran; Kumar, Collins (1998). Robbins pathologic basis ofdisease. philadelphia:W.B Saunders company. ISBN 0-7216-7335-X.
6. ParakramaChandrasoma, Clive R. Taylor (C. 2005). "Part A. General Pathology, Section II. The host response to injury, Chapter-3. The acute inflammatory response, Sub- Section Cardinal Clinical Signs". Concise pathology (3rd Edition Computer File Ed.).New York, N.Y.: Mcgraw-Hill. ISBN 0-8385-1499-5. OCLC 150148447.Retrieved2008-11-05.
7. Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD. Manifestations of systemic lupus erythematosus. Maedica. 2011 Oct;6(4):330. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391953/
8. Arthritis Drugs. arthritistoday.org
9. Shruti Srivastava, Pradeep Singh, Keshri K. Jha, Garima Mishra, Sourabh Srivastava and Rattan L. Khosa. Methodology 2012: 3(4): 204-208.
10. National Geographic (18 November 2008). Edible: an Illustrated Guide to the World’s Food Plants. National Geographic Books. P. 110. ISBN 978-1-4262- 0372-5.
11. Janick, Jules; Robert E. Paull (12 April 2008). The Encyclopedia of Fruit & Nuts. CABI. P.373. ISBN 978-0-85199-638-7.
12. Miller, Wilhelm (1901). Cyclopedia of American Horticulture. The Macmillan Company. P. 1318.
13. Leeya, Yuttapong; Mulvany, Michael J.; Queiroz, Emerson F.; Marston, Andrew; Hostettmann, Kurt; Jansakul, Chaweewan. Hypotensive activity of an n-butanol extract and their purified compounds from leaves of Phyllanthus acidus (L.) Skeels in rats. Euro J Pharmacology. 2010;649 (1–3):301–13. Doi:10.1016/j.ejphar.2010.09.038. PMID 20868659
14. Gopika Gopinath, Sujesh M, Dr. Babu. T.D, Evaluation of Cytotoxic and Anti-Tumor Activity of Phyllanthus Acidus (L.) Skeels Leaf Extracts, 2015; 2(2):19-26.
15. Foyzun T, Aktar K, Uddin MA. Evaluation of antioxidant, cytotoxic and antimicrobial activity of Phyllanthus acidus. Int J Pharmacogn Phytochem Res. 2016;8(11):1751-8.
16. Moniruzzaman M, Asaduzzaman M, Hossain MS, Sarker J, Rahman SA, Rashid M, Rahman MM. In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus. BMC complementary and alternative medicine. 2015 Dec;15:1-0. https://link.springer.com/article/10.1186/s12906-015-0930-y
17. Medline Plus. Juvenile idiopathic arthritis: Medical Encyclopedia. https://medlineplus.gov/ency/article/000451.htm#:~:text=Juvenile%20idiopathic%20arthritis%20(JIA)%20is,cause%20joint%20pain%20and%20swelling