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May 18, 2024
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May 18, 2024
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Abstract

Aim: The study aimed  to evaluate the analgesic and anti- inflammatory activity of ethanolic extract from Talinum Triangulare  on experimental study.


Methods:Talinum triangulare plant was extracted with ethanol and the leaves were dried, grind, and extracted with ethanol.The Phytochemical  analysis was conducted  using various test.Albino Wistar rats of either sex weighing (180-200g) and adult male albino mice (25-35g)were used in this study.Talinum Triangulare leaves extract was used to evaluate analgesic activity by acetic acid induced writhing method and anti-inflammatory activity by carrageenan-induced hind paw edema method.The study was conducted with prior approval of Institutional Animal Ethical Committee.


Result:In acetic acid induced writhing method,talinum triangulare shows analgesic activity which was statistically significant as compared to control(P<0.05) but less than aceclofenac sodium. In the model of acute inflammation i.e.,carrageenin -induced paw edema in rats , talinum triangulare shows anti -inflammatory activity which was statistically significant as compared to control(P<0.05) but less than indomethacin.


Conclusion: The result of this study suggests that the ethanolic extract of talinum triangulare leaves has a potential analgesic and anti-inflammatory activity.

Keywords

Anti-Inflammatory analgesic talinum triangulare

Article Details

How to Cite
Mumtaj Begum. A, Pavithra. K P S, Tamilselvan. G, & Senthil Kumar. K L. (2024). Evaluation of analgesic and anti-inflammatory activity of ethanolic extract from talinum triangulare on experimental animals. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(2), 126-133. Retrieved from https://ijrpp.com/ijrpp/article/view/542
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References

  1. 1. Kumar, Abbas, Faristo, Mitchell. Robbin’s Basic Pathology. 8th edition. chapter 2;31-58
  2. 2. Undewood JCE. General & systematic pathology,4th edition. Churchill Livingstone. Chapter 10: Inflammation, 2005;202.
  3. 3. USDA,Talinum triangulare [online]. Natural resource conservation service,plant Database,available at:https//plants.usda.gov/jawa/classification servlet? Source=display &classide=TATR2[Accessed on; 09.04.2020]
  4. 4. ITIS Standard Report page,talinum triangulare(Jacq).wild[online].Available at;hppts://www.itis.gov.
  5. 5. AOAC, 2005. International official methods of analysis. 18th ed. Gaithersburg, M.D.:AOAC International.
  6. 6. Harbourne, N. V., 1993. Phytochemical method: A guide to modern technique of plant analysis. 2nd ed. London: Fakenhamn Press Ltd.
  7. 7. Sofowora, A. E., 1993. Medicinal plants and traditional medicines in Africa. 2nd ed. Nigeria: Spectrum Books, Ibadan. p. 289.
  8. 8. Tiamiyu, A. M., 2019. Feed additive potentials and antibacterial effects of allium sativum, Chromolaena odorata and Talinum triangulare against Pseudomonas aeruginosa infection in clarias gariepinus burchell, 1822. PhD Thesis. University of Ibadan, Post Graduate School.
  9. 9. Liang D, Zhou Q, Gong W, Wang Y, Nie Z, He H, Li J, Wu J, Wu C, Zhang J. (2011). Studies on the antioxidant and hepatoprotective activities of polysaccharides from Talinum triangulare. Journal of Ethnopharmacol; 136(2):316–321. https://www.sciencedirect.com/science/article/pii/S0378874111002996
  10. 10. Ezekwe, C. I., Chidinma, R. U. and Okechukwu, P. C. U., The Effect of Methanol Extract of Talinum Triangulare (Water Leaf) on the Hematology and Some Liver Parameters of Experimental Rats, Global Journal of Biotechnology & Biochemistry. 2013; 8(2):51-60. https://www.academia.edu/download/80568839/3.pdf
  11. 11. Mensah J. K., Okoli R. I., Ohaju-Obodo J. O. and Eifediyi K. Phytochemical, nutritional and medical properties of some leafy vegetables consumed by Edo people of Nigeria. African Journal of Biotechnology, 2008; 7(14): 2304-2309. https://www.ajol.info/index.php/ajb/article/view/58988
  12. 12. Afolabi OB, Oloyede OI. Antioxidant Properties of the Extracts of Talinum Triangulare and its Effect on Antioxidant enzymes in Tissue Homogenate of Swiss Albino Rat. Toxicol Int. 2014 Sep-Dec;21(3):307-13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413415/
  13. 13. C.A. Winter, E.A. Risley, G.W. Nuss, Carrageenan-induced oedemain the hind paw of rat as an assay for anti-inflammatory activity, Proc. Soc. Exp. Biol. Ther. 1962;111: 544–547.
  14. 14. Tomlinson A, Appleton I, Moore AR, Gilroy DW, Willis D,Mitchell JA, Willoughby DA. Cyclo-oxygenase and nitric oxidesynthase isoforms in rat carrageenin-induced pleurisy. Br JPharmacol 1994;113:693–98. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510410/
  15. 15. Vinegar R, Truax JF, Selph JL, Voelker FA. Pathway of onset,development and decay of carrageenan pleurisy in the rat. FedProc 1982;41:2588-95. https://europepmc.org/article/med/6806127
  16. 16. Abdollahi M, Karimpour H and Monsef-Esfehani HR. Anti-nociceptive effects Of Teucrium polium L. total extract and essential oil in mouse writhing test. Pharmacol. Res. 2003; 48: 31-35. https://europepmc.org/article/med/6806127
  17. 17. Golshani S, Karamkhani F, Monsef-Esfehani HR and Abdollahi M. Anti-nociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test. J. Pharm. Pharm. Sci. 2004;7: 76-79.
  18. 18. Williamson EM, Okpako DT, Evans FJ. Selection, Preparation and Pharmacological Evaluation of Plant Materials. Vol. 1. Chichester: John Wiley; 1996. Pharmacological Methods in Phytotherapy Research; pp. 184–186.
  19. 19. Koster R, Anderson M, Debeer E J. Acetic acid for analgesic screening. Federation Proceeding. 1959;18:412–417 https://www.sid.ir/paper/540037/en
  20. 20. Florence N, Claire S, Olga V, Rafaël M, Pascale C, Serge T, Marie C, Fournié Z, Bernard P. Pain-suppressive effects on various nociceptive stimuli (thermal, Chemical, electrical and inflammatory) of the first orally active enkephalin-Metabolizing enzyme inhibitor RB 120. Pain. 1997;73(3):383–391. https://www.sciencedirect.com/science/article/pii/S0304395997001255
  21. 21. Francis G, Kerem Z, Makkar HP, Becker K. The biological action of saponins in animal systems: a review. British journal of Nutrition. 2002 Dec;88(6):587-605.
  22. 22. Vinegar R, Schreiber W, Hugo RJ. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther 1969; 166(1): 96- 103. https://jpet.aspetjournals.org/content/166/1/96.short
  23. 23. Mikami T, Miyasaka K. Effects of several anti-inflammatory drugs on the various parameters involved in the inflammatory response in rat carrageenin-induced pleurisy. European Journal of Pharmacology. 1983 Nov 11;95(1-2):1-2. https://www.sciencedirect.com/science/article/pii/0014299983902613
  24. 24. Tomlinson A, Appleton I, Moore AR, Gilroy DW, Willis D, Mitchell JA, Willoughby DA. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. British journal of pharmacology. 1994 Nov;113(3):693. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1510410/
  25. 25. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proceedings of the society for experimental biology and medicine. 1962 Dec;111(3):544-7. https://journals.sagepub.com/doi/abs/10.3181/00379727-111-27849