Main Article Content
Abstract
Ziziphus oenoplia Mill is medicinal herb, belongs to Rhamnaceae, commonly known as jackal jujube. The plant is used in India and Thailand traditional system of medicine for treatment of uterus inflammation, anthelmintic, spermatorrhoea, healing of cuts and boils. The literature look over revealed the presence of flavanoids, phenols, alkaloids, glycosides, pentacyclic triterpenes, carboxylic acids, aromatic compounds, nitro compounds, and esters. The plant exhibits antibacterial, antimicrobial, wound healing, anthelmintic, antioxidant, antihepatotoxic, antiplasmodial, anticancer, antinociceptive and antidiarrhoeal activity. The fresh leaves of Ziziphus oenoplia were authenticated, collected, shade dried and coarsely powdered, was extracted with hydroalcohol . The extract was concentrated and stored in air tight container for further use. The aim of the present research study was to carry out for the identification of bioactive moleculess from hydroalcoholic extract of Ziziphus oenoplia leaves by Gas chromatography- Mass spectroscopy (GC-MS). GC-MS chromatogram showed twenty bioactive molecules which may attribute to pharmacological properties.
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References
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References
1. Pullaiah T. Medicinal Plants in Andhra Pradesh. Illustrated Edn, Daya books 406-407, 2002.
2. Suksamrarn S, Suwannapoch N, Aunchai N, Kuno M, Ratananukul P, Haritakun R. Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var.brunoniana. Tetrahedron, 61: 1175-1180, 2005.
3. Pundir R, Singh G, Pandey AA, Saraf SA. Demand of herbal hepatoprotective formulations in Lucknow-A Survey. Pharmaceutical Research, 1: 23-33, 2009.
4. Jadhav SA, Prassanna SM. Evaluation of antiulcer activity of Ziziphus oenoplia (L.) Mill roots in rats. Asian Journal of Pharmaceutical and Clinical Research, 1(1): 92-95, 2011.
5. Jadhav SA, Chavan SD. In vitro antioxidant activity of Ziziphus oenoplia (L.) Mill Root extract. Journal of Pharmaceutical Science, 4(4): 586-588, 2012.
6. David B. In-vitro anti-denaturation and antibacterial activities of Zizyphus oenopli. Scholars Research Library Der Pharmacia Lettre, 2010; 2(1): 87-93.
7. Eswari LM, Bharathi VR, Jayshree N. Hypolipidemic Activity on Ethanolic Extract of Leaves of Ziziphus oenoplia (L) Mill International Journal of Pharmaceutical & Biological Archives, 2013; 4(1): 136-141.
8. Rao Ch V, Rawat AKS, Singh AP, Singh A, Verma N. Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia (L.) Mill roots against antitubercular drugs induced hepatotoxicity in experimental models. Asian Pacific Journal of Tropical Medicine.s 2 283- 288, 2012.
9. Ronald Hites A. Gas Chromatography Mass Spectroscopy: Handbook of Instrumental Techniques for Analytical Chemistry, 609-611, 1997.
10. Kell DB, Brown M, Davey HM, Dunn WB, Spasic I, Oliver SG. "Metabolic footprinting and systems biology. Nature Reviews Microbiology. 3:557-65, 2005.
11. Barathi Kannan. "Bioactive potential of 2-Methoxy-4-vinylphenol abd Benzofuran from Brassica oleracea L.var.capitate on oxidative and microbiological stability of beef meat. Foods, 9(5): 568, 2020.
12. Hardeep Kaur. Hybrid alkaloids an approach toward development of better antimalarial therapeutics. Studies in Natural Products Chemistry. 76: 199-245, 2023.
13. Natarajan P.GC-MS analysis of bioactive compounds present in Oeophylla smaragdiba. Research Journal of Pharmacy and Technology, 2019; 12(6): 2736-2741.
14. Pubchem.ncbi.nlm.nih.gov accessed on 2 April 2024.
15. Hagler et al. Salivary syndrome in Horses: Identification pf Slaframine in Red clover hay. Applied and Environmental Microbiology. 1067-1073, 1981.
16. National Institute of Standards and Technology- 28562-53-0.
17. Vijayabaskar G. Determination of phytocompounds in Withania somnifera and Smilax china using GC-MS technique. Journal of Pharmacognosy and Phytochemistry. 7(6):554-557, 2018.
18. Ahmed Darwish El-Gamal, Characterization of bioactive compounds with antioxidant activity and antimicrobial activity from freshwater cyanobacteria. Egyptian Journal of Chemistry. 723-735, 2022.
19. Sigma-Aldrich; N1252 accessed on 2 April 2024.