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Metformin-Associated Lactic Acidosis (MALA), a potential complication of metformin therapy in type 2 diabetes patients. It highlights the medication's role in managing blood glucose, its influence on renal function, and the associated risk factors, including age and comorbidities. The pathophysiology of MALA is explored, emphasizing how metformin affects mitochondrial function and leads to lactate accumulation and acidosis. A clinical case presentation underscores the real-world implications of this condition. The article concludes by stressing the importance of early recognition and discontinuation of metformin, ultimately encouraging healthcare providers to consider individualized patient risk factors when prescribing metformin.


diabetes, dialysis, drugs, MALA.

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How to Cite
Ayesha Firdous, Mirza Ismail Baig, Reshma Aijaz, Farheen Begum, & Syeda Saniya Kauser. (2024). Metformin Associated Lactic Acidosis: A Rare Life Threatening Complication. International Journal of Research in Pharmacology & Pharmacotherapeutics, 13(1), 24-30. Retrieved from


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