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Abstract
Pemphigus Vulgaris (PV) is a chronic auto immune bullous dermatosis. It is the most frequent and severe form of pemphigus occurring universally between 40 and 60 years of age. It is a life-threatening sickness causing blisters and erosions on the oral mucosa followed by lesions on the other mucous membranes and flaccid blisters on the skin, which can be disseminated. The underlying mechanism involves binding of immunoglobulin G auto anti-bodies to desmoglein (Dsg) 1 and 3, a transmembrane glycoprotein adhesion molecule present on desmosomes. Here a 47 years old male patient admitted in the Department of Dermatology with a chief complaint of multiple fluid filled lesions along with erosions present all over the body in the last 3 days. His past medical history revealed that he was suffering from this problem since one and half year and on corticosteroid medication, which provided temporary relief. The patient condition was not improved with the administration of corticosteroids but there may be a chance of improvement, if the treatment strategy was changed.
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References
- 1. Porro AM, Seque CArai, Ferreira MCC, Enokihara MMSES. Pemphigus vulgaris. An Bras Dermatol. 2019;94(3):264-78. doi: 10.1590/abd1806-4841.20199011, PMID 31365654.
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- 3. Sanders WJ. A brief review of pemphigus vulgaris. Biomed Dermatol. 2017;1(1):7. doi: 10.1186/s41702-017-0008-1.
- 4. Deo PN, Deshmukh RS. Revisiting pemphigus vulgaris: A case report and review of literature. Int J Case Rep Images 2023;14(2):91–96.
- 5. Joevitson DAM, Thangavelu DA, Pearl DE, Janarthanan D, Thiruneelakandan D. Pemphigus vulgaris: A case report. Int J Appl Dent Sci. 2020;6(4):367-70. doi: 10.22271/oral.2020.v6.i4f.1089.
- 6. Cianchini G, Corona R, Frezzolini A, Ruffelli M, Didona B, Puddu P. Treatment of severe pemphigus with rituximab: report of 12 cases and a review of the literature. Arch Dermatol. 2007;143(8):1033-8. doi: 10.1001/archderm.143.8.1033, PMID 17709662.
References
1. Porro AM, Seque CArai, Ferreira MCC, Enokihara MMSES. Pemphigus vulgaris. An Bras Dermatol. 2019;94(3):264-78. doi: 10.1590/abd1806-4841.20199011, PMID 31365654.
2. Banerjee I, Bhowmik B, Maji A, Sinha R. Pemphigus vulgaris – A report of three cases and review of literature. J Fam Med Prim Care. 2018;7(5, September-October):1109-12. doi: 10.4103/jfmpc.jfmpc_133_18, PMID 30598970.
3. Sanders WJ. A brief review of pemphigus vulgaris. Biomed Dermatol. 2017;1(1):7. doi: 10.1186/s41702-017-0008-1.
4. Deo PN, Deshmukh RS. Revisiting pemphigus vulgaris: A case report and review of literature. Int J Case Rep Images 2023;14(2):91–96.
5. Joevitson DAM, Thangavelu DA, Pearl DE, Janarthanan D, Thiruneelakandan D. Pemphigus vulgaris: A case report. Int J Appl Dent Sci. 2020;6(4):367-70. doi: 10.22271/oral.2020.v6.i4f.1089.
6. Cianchini G, Corona R, Frezzolini A, Ruffelli M, Didona B, Puddu P. Treatment of severe pemphigus with rituximab: report of 12 cases and a review of the literature. Arch Dermatol. 2007;143(8):1033-8. doi: 10.1001/archderm.143.8.1033, PMID 17709662.